Recent studies suggest that the association between a metronidazole-resistant anaerobe, Atopobium vaginae, and bacterial vaginosis (BV) warrants further investigation. In the present study, specific primers enhanced detection of A. vaginae and provided additional evidence that this bacterium is prevalent among patients with BV but absent among patients with normal vaginal flora.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC535275 | PMC |
| http://dx.doi.org/10.1128/JCM.42.12.5892-5894.2004 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Analysis of vaginal microbiota during postpartum and postmenopausal periods based on metagenomics.
BMC Microbiol
November 2024
Beijing Obstetrics and Gynecology Hospital, Beijing Maternal and Child Health Care Hospital, Capital Medical University, Beijing, 100026, China.
Background: Postmenopausal and the postpartum periods are essential physiological phases that result in low estrogen levels in women; however, they are important to female reproductive health. Traditional as well as new detection methods (such as 16 S RNA sequencing) have limitations in detecting the composition of vaginal microbiota. Therefore, in this study, we used metagenomic detection technology to study the composition of vaginal microbiota in postmenopausal and postpartum women.
View Article and Find Full Text PDFImmunometabolic Contributions of Atopobiaceae Family Members in Human Papillomavirus Infection, Cervical Dysplasia and Cancer.
J Infect Dis
November 2024
Department of Obstetrics and Gynecology, College of Medicine-Phoenix, University of Arizona, Phoenix, Arizona, USA.
Background: In the cervicovaginal environment, HPV acquisition and cervical cancer progression are linked to non-Lactobacillus dominance, of which Atopobiaceae are key taxa. We hypothesize that Atopobiaceae modulates the cervicovaginal microenvironment to promote HPV persistence and progression to cancer. However, the extent to which Atopobiaceae impact the immunometabolic microenvironment is poorly understood.
View Article and Find Full Text PDFHighlight signatures of vaginal microbiota and metabolome contributed to the occurrence and recurrence of vulvovaginal candidiasis.
Microbiol Spectr
October 2024
Center of Obstetrics and Gynecology, Peking University Shenzhen Hospital, Shenzhen, China.
Article Synopsis
- Vulvovaginal candidiasis (VVC) is a common infection with a high recurrence rate, defined as having four or more episodes in a year, which poses significant clinical challenges.
- In this study, researchers analyzed vaginal samples from 31 recurrent VVC patients, 28 VVC patients, and 29 healthy women, finding similarities in symptoms but noting increased swelling in the VVC group.
- The analysis revealed changes in the vaginal microbiota, including decreased beneficial bacteria and increased bacteria associated with bacterial vaginosis, highlighting the potential role of metabolites like L-glutamate in recurring infections, which may inform future treatment strategies.
Effects of Dietary Quality on Vaginal Microbiome Composition Throughout Pregnancy in a Multi-Ethnic Cohort.
Nutrients
October 2024
Department of Obstetrics and Gynecology, John A. Burns School of Medicine, University of Hawai'i, Honolulu, HI 96813, USA.
: Vaginal predominance is associated with improved vaginal health and reduced pregnancy complications. Little is known about how dietary quality may improve vaginal microbial composition or about dietary interventions that may promote abundance. To understand the host factors affecting vaginal microbiota during pregnancy in a multi-ethnic cohort in Hawai`i.
View Article and Find Full Text PDFDevelopment of a Multiplex Real-Time Quantitative PCR Assay for Detecting Vaginal Microbiota in Chinese Women - China, 2021-2022.
China CDC Wkly
August 2024
Clinical Center for HIV/AIDS, Beijing Ditan Hospital, Capital Medical University, Beijing, China.
Introduction: The Nugent score, limited by subjectivity and personnel requirements, lacks accuracy. Establishing a precise and simple molecular test is therefore essential for detecting vaginal microbiota compositions and evaluating vaginal health.
Methods: We evaluated the vaginal health of Chinese women using quantitative polymerase chain reaction (qPCR) to target (, , (, (, and .
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!