Synthesis of aryl sialosides using Mitsunobu conditions.

Carbohydr Res

Institute of Molecular Pharmacy, Pharmacenter of the University of Basel, Klingelbergstrasse 50, CH-4056 Basel, Switzerland.

Published: December 2004

Mitsunobu conditions for the efficient synthesis of aryl alpha/beta-sialosides were developed. An oxidative work-up procedure was employed to avoid a cumbersome chromatographic separation from the 2,3-dehydro derivative of sialic acid, which is formed as a side-product.

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http://dx.doi.org/10.1016/j.carres.2004.10.003DOI Listing

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