The paper describes the dominating role of surface tension (ST) on the modeling, monitoring, and estimating pK(a) for a large series of 43 substituted sulfonamides. Because of the direct correlation of ST with parachor (Pc) vis-a-vis molecular volume (MV), ST is considered as a steric parameter. Single as well as multi-parametric regressions have indicated that ST has a dominating role in QSAR of the set of sulfonamides used and that excellent results are obtained in multi-parametric regression analysis. The results are discussed critically on the basis of statistical parameters.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.bmcl.2004.10.032 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Precession modulates the poleward expansion of atmospheric circulation to the Arctic Ocean.
Nat Commun
January 2025
Centre for Marine Magnetism (CM2, Department of Ocean Science and Engineering, Southern University of Science and Technology, Shenzhen, 518055, China.
Under sustained global warming, Arctic climate is projected to become more responsive to changes in North Pacific meridional heat transport as a result of teleconnections between low and high latitudes, but the underlying mechanisms remain poorly understood. Here, we reconstruct subarctic humidity changes over the past 400 kyr to investigate the role of low-to-high latitude interactions in regulating Arctic hydroclimate. Our reconstruction is based on precipitation-driven sediment input variations in the Subarctic North Pacific (SANP), which reveal a strong precessional cycle in subarctic humidity under the relatively low eccentricity variations that dominated the past four glacial-interglacial cycles.
View Article and Find Full Text PDFLow Abundance of Regular Pollinators and Indirect Competitive Effects of Dominant Small Bees Negatively Affect Passion Fruit Pollination in Smallholder Croplands.
Neotrop Entomol
January 2025
Depto de Ecologia, Instituto de Ciências Biológicas, Univ de Brasília (UnB), Brasília, DF, Brazil.
Land-use changes have led to natural habitat loss and fragmentation, favoring the occurrence of dominant bee species in agroecosystems. This has raised concerns on the dominance effects in pollination-dependent crops like passion fruits (Passiflora edulis Sims) in tropical regions. That is because dominant bee species might overlap their foraging time with regular pollinators, potentially impairing crop yield.
View Article and Find Full Text PDFContrasting drought sensitivity of Eurasian and North American grasslands.
Nature
January 2025
School of Life Sciences, Hebei University, Baoding, China.
Extreme droughts generally decrease productivity in grassland ecosystems with negative consequences for nature's contribution to people. The extent to which this negative effect varies among grassland types and over time in response to multi-year extreme drought remains unclear. Here, using a coordinated distributed experiment that simulated four years of growing-season drought (around 66% rainfall reduction), we compared drought sensitivity within and among six representative grasslands spanning broad precipitation gradients in each of Eurasia and North America-two of the Northern Hemisphere's largest grass-dominated regions.
View Article and Find Full Text PDFEffects of stratified microbial extracellular polymeric substances on microalgae dominant biofilm formation and nutrients turnover under batch and semi-continuous operation.
Bioresour Technol
January 2025
MOE Key Laboratory of Bio-Intelligent Manufacturing, School of Bioengineering, Dalian University of Technology, Dalian 116024 PR China.
Extracellular polymeric substances (EPS) are well-acknowledged to accelerate microalgal biofilm formation, yet specific role of stratified EPS is unknown. Bacterial biofilm stratified EPS could enrich phosphorus, whether microalgal biofilm stratified EPS could also realize phosphorus or nitrogen enrichment remains unclarified. This study investigated microalgae dominant biofilm growth characteristics and nutrients removal via inoculating microalgae and stratified bacterial EPS at various microalgae:bacteria ratios.
View Article and Find Full Text PDFMitral Valve Prolapse Caused by TLL1 Gain-of-Function Mutation.
Can J Cardiol
January 2025
The Morris Kahn Laboratory of Human Genetics, Faculty of Health Sciences and National Institute of Biotechnology in the Negev, Ben Gurion University of the Negev, Be'er Sheva, Israel; Genetics Institute, Soroka University Medical Center, Be'er Sheva, Israel; The Danek Gertner Institute of Human Genetics, Sheba Medical Center, Ramat Gan, Israel. Electronic address:
Background: Mitral valve prolapse (MVP) is a common cardiac valvular anomaly that can be caused by mutations in genes of various biological pathways. Individuals of three generations of a kindred presented with apparently dominant heredity of isolated MVP.
Methods: Clinical evaluation and echocardiography for all complying family members (n=13).
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!