AI Article Synopsis
- Two new analogs of yessotoxin were discovered from the marine algae Protoceratium reticulatum.
- Their chemical structures were determined using advanced techniques like NMR spectroscopy and LC-MS3.
- Testing showed no toxic effects in mice even at high doses.
Article Abstract
Two analogs of yessotoxin were isolated from extracts of a culture of Protoceratium reticulatum. The structures of the analogs were identified as trihydroxylated amides of 41a-homoyessotoxin (1) and 9-methyl-41a-homoyessotoxin (2) by one- and two-dimensional 1H and 13C NMR spectroscopy and LC-MS3 analyses. Structures were further confirmed by micro-scale chemical conversions combined with LC-MS3 analyses. No toxic effects were recorded in mice injected intraperitoneally with 2 at a dose of 5000 microg/kg.
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| http://dx.doi.org/10.1016/j.toxicon.2004.09.011 | DOI Listing |
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