Download full-text PDF |
Source |
---|---|
http://dx.doi.org/10.1016/j.advenzreg.2003.11.009 | DOI Listing |
Nat Commun
November 2024
Department of Chemical and Biological Engineering, Princeton University, Princeton, NJ, USA.
Cell migration through small constrictions during cancer metastasis requires significant deformation of the nucleus, with associated mechanical stress on the nuclear lamina and chromatin. However, how mechanical deformation impacts various subnuclear structures, including protein and nucleic acid-rich biomolecular condensates, is largely unknown. Here, we find that cell migration through confined spaces gives rise to mechanical deformations of the chromatin network, which cause embedded nuclear condensates, including nucleoli and nuclear speckles, to deform and coalesce.
View Article and Find Full Text PDFPhys Rev Lett
October 2024
CERN, Geneva, Switzerland.
Phys Rev Lett
October 2024
CERN, Geneva, Switzerland.
Phys Rev Lett
September 2024
CERN, Geneva, Switzerland.
This Letter presents the first study of the energy dependence of diboson polarization fractions in WZ→ℓνℓ^{'}ℓ^{'}(ℓ,ℓ^{'}=e,μ) production. The dataset used corresponds to an integrated luminosity of 140 fb^{-1} of proton-proton collisions at a center-of-mass energy of 13 TeV recorded by the ATLAS detector. Two fiducial regions with an enhanced presence of events featuring two longitudinally polarized bosons are defined.
View Article and Find Full Text PDFBMB Rep
September 2024
Department of Biomedical Science & Engineering, Dankook University, Cheonan 31116, Korea.
The nucleus, a highly organized and dynamic organelle, plays a crucial role in regulating cellular processes. During cell differentiation, profound changes occur in gene expression, chromatin organization, and nuclear morphology. This review explores the intricate relationship between nuclear architecture and cellular function, focusing on the roles of the nuclear lamina, nuclear pore complexes (NPCs), sub-nuclear bodies, and the nuclear scaffold.
View Article and Find Full Text PDFEnter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!