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Antipsychotic-induced akathisia in adults with acute schizophrenia: A systematic review and dose-response meta-analysis.
Eur Neuropsychopharmacol
July 2023
Department of Psychiatry and Psychotherapy, School of Medicine, Technical University of Munich, Munich, Germany; Institute of Psychiatry, Psychology and Neuroscience, Department of Psychiatry, Department of Psychosis Studies, King's College London, London, UK.
Antipsychotic-induced akathisia is severely distressing. We aimed to investigate relationships between antipsychotic doses and akathisia risk. We searched for randomised controlled trials that investigated monotherapy of 17 antipsychotics in adults with acute schizophrenia until 06 March 2022.
View Article and Find Full Text PDFInhibitory Effects of Antipsychotics on the Contractile Response to Acetylcholine in Rat Urinary Bladder Smooth Muscles.
Biol Pharm Bull
December 2021
Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, Toho University.
The clinical applications of antipsychotics for symptoms unrelated to schizophrenia, such as behavioral and psychological symptoms, in patients with Alzheimer's disease, and the likelihood of doctors prescribing antipsychotics for elderly people are increasing. In elderly people, drug-induced and aging-associated urinary disorders are likely to occur. The most significant factor causing drug-induced urinary disorders is a decrease in urinary bladder smooth muscle (UBSM) contraction induced by the anticholinergic action of therapeutics.
View Article and Find Full Text PDFCharacterization of binding of antipsychotics to muscarinic receptors using mouse cerebral cortex.
J Pharmacol Sci
June 2019
Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, Toho University, Miyama 2-2-1, Funabashi, Chiba, 274-8510, Japan.
Antipsychotics are often the first-line treatment for behavioral and psychological symptoms of dementia. However, the potential anticholinergic effects of antipsychotics could counteract the therapeutic effects of cholinesterase inhibitors used to treat dementia. We investigated the inhibitory effects of 26 antipsychotics on [N-Methyl-H]scopolamine specific binding in mouse cerebral cortex.
View Article and Find Full Text PDFAntipsychotic drug use and pneumonia: Systematic review and meta-analysis.
J Psychopharmacol
November 2018
3 Department of Psychiatry, Hamad Medical Corporation, Doha, Qatar.
Objectives: The purpose of this study was to investigate the association of antipsychotic exposure to the incidence and mortality of pneumonia.
Methods: The design of this study involved meta-analysis of observational studies identified from electronic databases.
Results: In total, 19 studies were included in the systematic review and 14 in the meta-analysis.
Time to Discontinuation of Second-Generation Antipsychotics Versus Haloperidol and Sulpiride in People With Schizophrenia: A Naturalistic, Comparative Study.
J Clin Psychopharmacol
February 2017
From the *Department of General Psychiatry, Taoyuan Psychiatric Center, Taoyuan; and †Department of Psychiatry, National Taiwan University Hospital and School of Medicine, National Taiwan University; ‡Department of Psychiatry, Far Eastern Memorial Hospital; and §Department of Public Health, School of Medicine, National Yang-Ming University, Taipei, Taiwan.
Purpose: A retrospective study was conducted to evaluate the time to discontinuation (TTD) of the first- (FGAs) and second-generation antipsychotics (SGAs).
Methods: In total, 918 treatment episodes of patients with schizophrenia, initiated on one of the investigated drugs on an outpatient basis during 2004-2006, were entered into the study. The primary outcome was the duration of the investigated treatment episode.
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