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Management of atraumatic chin-on-chest deformity in newly diagnosed multiple myeloma: illustrative case.
J Neurosurg Case Lessons
December 2024
Department of Neurosurgery, Rhode Island Hospital, Warren Alpert School of Medicine at Brown University, Providence, Rhode Island.
Article Synopsis
- Multiple myeloma (MM) patients are treated by multidisciplinary teams, with surgery needed for serious issues like instability or neurological problems; otherwise, chemotherapy and radiotherapy are main treatments.
- A 66-year-old man with a kyphotic chin-on-chest deformity due to undiagnosed spinal MM experienced severe neck pain and limited daily activities, leading to significant imaging findings that indicated severe bone damage.
- His treatment involved halo traction to realign his spine and improve bone density, followed by surgery for decompression and fusion, resulting in symptom improvement and stability without complications a year later.
Coloniality is strongly shaped by aspects of social foraging behaviour. For example, colonies may be important sources of information, while food competition may increase foraging efforts and limit colony size. Understanding foraging ecology considering these apparent trade-offs is required to develop a better understanding of colonial living.
View Article and Find Full Text PDFThe Youth Fitness International Test (YFIT) battery for monitoring and surveillance among children and adolescents: A modified Delphi consensus project with 169 experts from 50 countries and territories.
J Sport Health Sci
November 2024
Department of Physical Education and Sports, Faculty of Sport Sciences, Sport and Health University Research Institute (iMUDS), University of Granada; and CIBEROBN Physiopathology of Obesity and Nutrition; Granada, ES18071, Spain.
Background: Physical fitness in childhood and adolescence is associated with a variety of health outcomes and is a powerful marker of current and future health. However, inconsistencies in tests and protocols limit international monitoring and surveillance. The objective of the study was to seek international consensus on a proposed, evidence-informed, Youth Fitness International Test (YFIT) battery and protocols for health monitoring and surveillance in children and adolescents aged 6-18 years.
View Article and Find Full Text PDFSpontaneously Blinkogenic Probe for Wash-Free Single-Molecule Localization-Based Super-Resolution Imaging in Living Cells.
Angew Chem Int Ed Engl
November 2024
Dalian Institute of Chemical Physics, Chinese Academy of Sciences, 457 Zhongshan Road, Dalian, 116023, China.
Single-molecule localization super-resolution fluorescence imaging relies on the fluorescence ON/OFF switching of fluorescent probes to break the diffraction limit. However, the unreacted or nonspecifically bound probes cause non-targeted ON/OFF switching, resulting in substantial fluorescence background that significantly reduces localization precision and accuracy. Here, we report a blinkogenic probe HM-DS655-Halo that remains blinking OFF until it binds to HaloTag, thereby triggering its self-blinking activity and enabling its application in direct SMLM imaging in living cells without wash-out steps.
View Article and Find Full Text PDFA Fluorogenic Chemogenetic pH Sensor for Imaging Protein Exocytosis.
ACS Sens
September 2024
Laboratoire des biomolécules, LBM, Département de chimie, École normale supérieure, PSL University, Sorbonne Université, CNRS, 75005 Paris, France.
Fluorescent protein-based pH biosensors enable the tracking of pH changes during protein trafficking and, in particular, exocytosis. The recent development of chemogenetic reporters combining synthetic fluorophores with self-labeling protein tags offers a versatile alternative to fluorescent proteins that combines the diversity of chemical probes and indicators with the selectivity of the genetic encoding. However, this hybrid protein labeling strategy does not avoid common drawbacks of organic fluorophores such as the risk of off-target signal due to unbound molecules.
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