Background: Paraoxonase-1 (PON1) is an enzyme that prevents low-density lipoprotein (LDL) oxidation. The role of polymorphisms of PON1 determining early atherosclerotic changes is currently unclear.
Design: Cross sectional cohort study.
Methods: Nine hundred and ninety-nine subjects from a population-based cohort were screened. Intima-media thickness (IMT) was measured by ultrasonography. Leu-Met55 and Gln-Arg192 polymorphism were determined.
Results: No association between PON1 genotypes and IMT was found. This finding remained after adjusting for confounding factors.
Conclusions: The PON1 Leu-Met55 and Gln-Arg192 polymorphisms are not major risk factors for atherosclerosis in the general Caucasian population.
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| http://dx.doi.org/10.1097/01.hjr.0000136415.17146.38 | DOI Listing |
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Paraoxonase-1 gene Leu-Met55 and Gln-Arg192 polymorphisms are not associated with carotid artery atherosclerosis in a population-based cohort.
Eur J Cardiovasc Prev Rehabil
December 2004
Department of Internal Medicine, University of Oulu, Finland.
Background: Paraoxonase-1 (PON1) is an enzyme that prevents low-density lipoprotein (LDL) oxidation. The role of polymorphisms of PON1 determining early atherosclerotic changes is currently unclear.
Design: Cross sectional cohort study.
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