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Targeting chaperone-mediated autophagy in neurodegenerative diseases: mechanisms and therapeutic potential.
Acta Pharmacol Sin
November 2024
Department of Pharmacy, The Fourth Affiliated Hospital of Soochow University, Suzhou Dushu Lake Hospital, Medical Center of Soochow University, Suzhou, 215123, China.
The pathological hallmarks of various neurodegenerative diseases including Parkinson's disease and Alzheimer's disease prominently feature the accumulation of misfolded proteins and neuroinflammation. Chaperone-mediated autophagy (CMA) has emerged as a distinct autophagic process that coordinates the lysosomal degradation of specific proteins bearing the pentapeptide motif Lys-Phe-Glu-Arg-Gln (KFERQ), a recognition target for the cytosolic chaperone HSC70. Beyond its role in protein quality control, recent research underscores the intimate interplay between CMA and immune regulation in neurodegeneration.
View Article and Find Full Text PDFChaperone in breast examination: a comprehensive systematic review of patient and clinician perspectives, and documentation.
Ir J Med Sci
December 2024
Queens Medical Centre, Nottingham, England, United Kingdom.
Background: The General Medical Council (GMC) has made it mandatory to have a chaperone present during intimate examinations, including breast exams, highlighting the importance of medicolegal protection for both patients and clinicians.
Aims: The use of chaperones during breast examinations is logical, especially in an increasingly litigious society. This review aims to summarize current information regarding patients' and clinicians' perspectives on chaperone use in breast examination.
Structural roles of Ump1 and β-subunit propeptides in proteasome biogenesis.
Life Sci Alliance
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Institute of Biochemistry and Biology, Department of Biochemistry, University of Potsdam, Potsdam-Golm, Germany
The yeast (β4-S142F) mutant accumulates late 20S proteasome core particle precursor complexes (late-PCs). We report a 2.1 Å cryo-EM structure of this intermediate with full-length Ump1 trapped inside, and Pba1-Pba2 attached to the α-ring surfaces.
View Article and Find Full Text PDFLysosomal dysfunction in α-synuclein pathology: molecular mechanisms and therapeutic strategies.
Cell Mol Life Sci
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Department of Neurology, Renmin Hospital of Wuhan University, Wuhan, 430060, China.
In orchestrating cell signaling, facilitating plasma membrane repair, supervising protein secretion, managing waste elimination, and regulating energy consumption, lysosomes are indispensable guardians that play a crucial role in preserving intracellular homeostasis. Neurons are terminally differentiated post-mitotic cells. Neuronal function and waste elimination depend on normal lysosomal function.
View Article and Find Full Text PDFSynthetic antibodies for accelerated RNA crystallography.
Wiley Interdiscip Rev RNA
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Department of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, Indiana, USA.
RNA structure is crucial to a wide range of cellular processes. The intimate relationship between macromolecular structure and function necessitates the determination of high-resolution structures of functional RNA molecules. X-ray crystallography is the predominant technique used for macromolecular structure determination; however, solving RNA structures has been more challenging than their protein counterparts, as reflected in their poor representation in the Protein Data Bank (<1%).
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