The behavioural and electrocortical (ECoG) effects induced by a methanol extract of the skin of the Australian frog Pseudophryne coriacea, directly microinjected into several areas of the brain, were studied in freely moving rats. Administration of the P. coriacea extract (5, 10, 15 and 20 micrograms) into the dorsal hippocampus produced a dose-dependent and reversible behavioural stimulation and ECoG spikes lasting 20-140 min. Similar but less intense effects were elicited in rats receiving injections into the III cerebral ventricle, amygdala and caudate nucleus. In conclusion, the present experiments show that the skin extract of P. coriacea produces behavioural stimulation and ECoG spikes when injected into the rat brain, the most sensitive area being the hippocampus.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/0041-0101(92)90472-h | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Protein Structural Modeling and Transport Thermodynamics Reveal That Plant Cation-Chloride Cotransporters Mediate Potassium-Chloride Symport.
Int J Mol Sci
December 2024
School of Agriculture, Food and Wine, Waite Research Institute, Faculty of Sciences, Engineering and Technology, University of Adelaide, Waite Campus Precinct, Glen Osmond, Adelaide, SA 5064, Australia.
Plant cation-chloride cotransporters (CCCs) are proposed to be Na-K-2Cl transporting membrane proteins, although evolutionarily, they associate more closely with K-Cl cotransporters (KCCs). Here, we investigated grapevine ( L.) VvCCC using 3D protein modeling, bioinformatics, and electrophysiology with a heterologously expressed protein.
View Article and Find Full Text PDFA new Oreolalax (Anura: Megophryidae) from the Hoang Lien Range, northwest Vietnam.
Zootaxa
October 2024
The megophryid genus Oreolalax is comprised of 19 species, most of which are endemic to China. A single species, Oreolalax sterlingae, is the only member of the genus known from Vietnam. During fieldwork on Mount Po Ma Lung in the Hoang Lien Range of northwest Vietnam, we encountered individuals of both Oreolalax sterlingae and another, morphologically divergent species of Oreolalax.
View Article and Find Full Text PDFThe frog fauna of New Guinea is exceptionally diverse but very poorly known. Here we describe a new species of pelodryadid treefrog that is currently known only from two specimens from a single site in Hela Province in the highlands of Papua New Guinea. Genetic data show that the new species is closely related to the torrent-breeding species Litoria angiana (Boulenger, 1915) from which it can be readily distinguished by its more slender body and limbs, relatively long forelimbs, and aspects of body colouration and tuberculation.
View Article and Find Full Text PDFA new species of the little-known genus Australotaenia de Chambrier & de Chambrier, 2010 is described from Ranoidea australis (Gray) (Anura: Hylidae), commonly known as the giant frog, northern snapping frog or round frog and which is a burrowing frog species native to Australia. Australotaenia hobbsi n. sp.
View Article and Find Full Text PDFCross-dataset Evaluation of Dementia Longitudinal Progression Prediction Models.
medRxiv
November 2024
Centre for Sleep and Cognition (CSC) & Centre for Translational Magnetic Resonance Research (TMR), Yong Loo Lin School of Medicine, National University of Singapore, Singapore.
Accurate Alzheimer's Disease (AD) progression prediction is essential for early intervention. The TADPOLE challenge, involving 92 algorithms, used multimodal biomarkers to predict future clinical diagnosis, cognition, and ventricular volume. The winning algorithm, FROG, utilized a Longitudinal-to-Cross-sectional (L2C) transformation to convert variable longitudinal histories into fixed-length feature vectors, which contrasted with most existing approaches that fitted models to entire longitudinal histories, e.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!