AI Article Synopsis
- Endothelial progenitor cells (EPCs) are crucial for repairing blood vessels after ischemic events, but little is known about their role in cerebrovascular disease.
- In a study, EPC counts were significantly lower in stroke patients (both acute and stable) compared to healthy controls, indicating a potential link to cerebrovascular issues.
- The study also found a correlation between EPC levels and the Framingham coronary risk score, suggesting that low EPC counts could contribute to the development of cerebrovascular diseases.
Article Abstract
Background And Purpose: Endothelial progenitor cells (EPCs) are associated with endothelial repair after ischemia in cardiac or peripheral circulation. There are no reports of EPCs with cerebrovascular disease. We present our experience with EPCs in patients with cerebrovascular disease.
Summary Of Report: EPC counts differed significantly (P<0.001) between stroke patients (acute stroke: median 4.75 and range 0 to 33; stable stroke: median 7.25 and range 0 to 43) and control subjects (median 15.5 and range 4.3 to 50), independent of age. The level of EPCs was significantly correlated with the Framingham coronary risk score (FCRS) (rho=-0.349; P=0.002).
Conclusions: Similar to cardiac experience, the low EPC levels may play a role in the pathophysiology of cerebrovascular disease.
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| http://dx.doi.org/10.1161/01.STR.0000149944.15406.16 | DOI Listing |
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