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| http://dx.doi.org/10.1177/014107680409701226 | DOI Listing |
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[Efficacy and toxicity of brexucabtagene autoleucel in the treatment of high-risk mantle cell lymphoma: description of a clinical case.].
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SC Ematologia, Aou Città della Salute e della Scienza di Torino.
Introduction: Relapsed or refractory (R/R) mantle cell lymphoma (MCL) represent a setting at unfavourable prognosis. Chimeric antigen receptor T-cells (CAR-T) are recently introduced in clinical practice as a new therapeutic option for this setting.
Clinical Case: 61-year-old man with MCL pleomorphic variant, TP53 mutated with high risk MIPI-c early relapsed after frontline immunochemotherapy and ibrutinib.
Telomere length and telomerase reverse transcriptase gene polymorphism as potential markers of complete chimerism and GvHD development after allogeneic haematopoietic stem cell transplantation.
J Cancer Res Clin Oncol
March 2025
Laboratory of Clinical Immunogenetics and Pharmacogenetics, Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Wroclaw, Poland.
Introduction: Telomerase reverse transcriptase (TERT) is a catalytic subunit of telomerase that maintains genome stability by maintaining telomere length (TL). The massive proliferation of donor cells in the recipient's body for engraftment results in accelerated telomere shortening. Genetic variability within the TERT gene affects telomerase activity, and was shown to influence of haematopoietic stem cell transplantation (HSCT) outcome.
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BMJ Case Rep
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Ophthalmology, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA.
An elderly woman presented with subacute, bilateral, severe vision loss and pronounced panuveitis. She also noted a skin lesion on her ankle, and biopsy of the lesion revealed necrotising vasculitis and granulomatous inflammation of small vessels. Although the organ involvement in this case is atypical, a granulomatosis with polyangiitis (GPA)-like syndrome was suspected.
View Article and Find Full Text PDFChallenging diagnosis of haemophagocytic lymphohistiocytosis secondary to T-cell/histiocyte-rich large B-cell lymphoma.
BMJ Case Rep
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Allergy Immunology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.
Haemophagocytic lymphohistiocytosis (HLH) is a rare, life-threatening disorder of uncontrolled immune activation by macrophages, cytotoxic T cells and natural killer (NK) cells, marked by severe inflammation. It is often categorised as primary (genetic) or secondary (acquired). Here, a case of a young male with a history of stage IA seminoma in remission, who presented with persistent fevers, night sweats, weight loss and fatigue, is reported.
View Article and Find Full Text PDFImpact of functional capacity before hematopoietic stem cell transplantation on the length of hospital stay.
Support Care Cancer
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Hospital de Clínicas de Porto Alegre (HCPA), Federal University of Rio Grande do Sul (UFRGS), Porto Alegre, Brazil.
Objective: To verify the association between pre-HSCT functional capacity and the variables of pulmonary function, fatigue, and length of hospital stay.
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