AI Article Synopsis
- The electroretinogram (ERG) is a key tool for studying retinal function in both clinic and research settings, and contact lens electrodes (CLEs) are commonly used for these recordings.
- Manufacturing small CLEs for mice has been challenging, but new instruments and methods have been developed for easy and cost-effective production.
- The new CLEs allow for stable, long-term ERG recordings in mice, and could potentially be adapted for use in other small animals like rats or fish.
Article Abstract
The electroretinogram (ERG) is routinely used to study retinal physiology in the clinic and in research. Due to their outstanding properties, contact lens electrodes (CLEs) are widely used for ERG recordings. Though the procedures for ERG recordings in mice are similar to those used in humans and larger vertebrates, use of CLEs in the mouse has been limited because of difficulties involved with the manufacturing of small contact lenses. We describe a simple instrument and method for manufacturing contact lenses and CLEs for stable ERG recordings in mice. The instrument operates like a hole-punch and is based on slip joint pliers incorporating a ball bearing on one jaw and forming plate on the other. These CLEs are simple to manufacture, inexpensive and provide stable, long-term recordings of corneal ERGs in mice. With minor modifications, these CLEs could be made for other small animals such as rats or fish.
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| http://dx.doi.org/10.1007/s10633-004-5734-1 | DOI Listing |
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