AI Article Synopsis
- The natural avermectin complex, aversectin C, and avermectin B1 were studied for their effects on the growth of ascitic and solid tumors in animals, revealing significant antitumor activity.
- Aversectin C showed strong inhibition of P388 lymphoid leukemia and Ehrlich carcinoma, with tumor growth reduced by 70 to 80% at subtoxic doses.
- The most effective administration of aversectin C was through intraperitoneal injection, while avermectin B1 specifically inhibited the growth of solid Ehrlich carcinoma and carcinoma 755.
Article Abstract
The effects of the natural avermectin complex, aversectin C and individual avermectin B1 on the growth of ascitic and solid transplantable tumors in animals were studied. The results showed for the first time that both aversectin C and avermectin B1 possessed marked antitumor activity. In subtoxic doses aversectin C significantly inhibited the growth of P388 lymphoid leukemia and Ehrlich carcinoma, both ascitic and solid ones. In some administration regimens aversectin C inhibited the tumor growth by 70 to 80%. The highest effect of aversectin C was observed after its intraperitoneal administration. Avermectin B1 inhibited the growth of solid Ehrlich carcinoma and carcinoma 755.
Download full-text PDF |
Source |
|---|
Publication Analysis
Top Keywords
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!