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Multicellular model of neuroblastoma proposes unconventional therapy based on multiple roles of p53.
PLoS Comput Biol
December 2024
Insigneo Institute for in Silico Medicine, University of Sheffield, Sheffield, United Kingdom.
Neuroblastoma is the most common extra-cranial solid tumour in children. Over half of all high-risk cases are expected to succumb to the disease even after chemotherapy, surgery, and immunotherapy. Although the importance of MYCN amplification in this disease is indisputable, the mechanistic details remain enigmatic.
View Article and Find Full Text PDFQuantitative Systems Pharmacology Modeling in Immuno-Oncology: Hypothesis Testing, Dose Optimization, and Efficacy Prediction.
Handb Exp Pharmacol
December 2024
Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Despite an increasing number of clinical trials, cancer is one of the leading causes of death worldwide in the past decade. Among all complex diseases, clinical trials in oncology have among the lowest success rates, in part due to the high intra- and inter-tumoral heterogeneity. There are more than a thousand cancer drugs and treatment combinations being investigated in ongoing clinical trials for various cancer subtypes, germline mutations, metastasis, etc.
View Article and Find Full Text PDFAdvancing personalised care in atrial fibrillation and stroke: The potential impact of AI from prevention to rehabilitation.
Trends Cardiovasc Med
December 2024
Liverpool Centre for Cardiovascular Science at University of Liverpool, Liverpool John Moores University and Liverpool Heart & Chest Hospital, Liverpool, UK; Danish Center for Health Services Research, Department of Clinical Medicine, Aalborg University, Aalborg, Denmark; Medical University of Bialystok, Bialystok, Poland.
Atrial fibrillation (AF) is a complex condition caused by various underlying pathophysiological disorders and is the most common heart arrhythmia worldwide, affecting 2 % of the European population. This prevalence increases with age, imposing significant financial, economic, and human burdens. In Europe, stroke is the second leading cause of death and the primary cause of disability, with numbers expected to rise due to ageing and improved survival rates.
View Article and Find Full Text PDFDental Anomalies in the Past: Fusion, Gemination, and Talon Cusp in Two Archeological Samples.
Int J Paediatr Dent
December 2024
Institut für Geowissenschaften, Goethe-Universität Frankfurt am Main, Frankfurt, Germany.
Background: Disruption in odontogenesis can influence the normal development of both deciduous and permanent dentition resulting in anomalies in morphology, number, and position of teeth. Although dental anomalies are frequently reported in clinical practice, their occurrence in past populations from archeological contexts is rarely acknowledged.
Aim: To describe two cases of dental anomalies on two non-adult individuals from Italian archeological sites.
A multiscale model of immune surveillance in micrometastases gives insights on cancer patient digital twins.
NPJ Syst Biol Appl
December 2024
Intelligent Systems Engineering, Indiana University, Bloomington, IN, USA.
Metastasis is the leading cause of death in patients with cancer, driving considerable scientific and clinical interest in immunosurveillance of micrometastases. We investigated this process by creating a multiscale mathematical model to study the interactions between the immune system and the progression of micrometastases in general epithelial tissue. We analyzed the parameter space of the model using high-throughput computing resources to generate over 100,000 virtual patient trajectories.
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