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Short-Term Safety of Paroxetine Plus Low-Dose Mirtazapine During Lactation.
Breastfeed Med
March 2019
Department of Psychiatry, Meram Faculty of Medicine, Necmettin Erbakan University, Konya, Turkey .
Selective serotonin reuptake inhibitors (SSRIs), especially sertraline and paroxetine, are first-line antidepressants in the treatment of postpartum depression in breastfeeding women as these drugs are well tolerated by most breastfed infants. Although some women with these diagnoses require additional antidepressants to SSRIs, the safety of combined usage of SSRIs and mirtazapine is currently unknown. This report includes short-term safety data of breastfed infants exposed to paroxetine plus low-dose mirtazapine.
View Article and Find Full Text PDFThe Safety, Tolerability and Risks Associated with the Use of Newer Generation Antidepressant Drugs: A Critical Review of the Literature.
Psychother Psychosom
July 2017
Department of Clinical Medicine and Translational Psychiatry Research Group, Faculty of Medicine, Federal University of Ceará, Fortaleza, Brazil.
Newer generation antidepressant drugs (ADs) are widely used as the first line of treatment for major depressive disorders and are considered to be safer than tricyclic agents. In this critical review, we evaluated the literature on adverse events, tolerability and safety of selective serotonin reuptake inhibitors, serotonin noradrenaline reuptake inhibitors, bupropion, mirtazapine, trazodone, agomelatine, vilazodone, levomilnacipran and vortioxetine. Several side effects are transient and may disappear after a few weeks following treatment initiation, but potentially serious adverse events may persist or ensue later.
View Article and Find Full Text PDFMirtazapine in pregnancy and lactation - A systematic review.
Eur Neuropsychopharmacol
January 2016
Department of Psychiatry, OLVG West Medical Center /VU Medical Center, Amsterdam, The Netherlands. Electronic address:
Depression is common in pregnancy and associated with increased risk of adverse effects for the neonate. Treatment and prevention options include antidepressant therapy. The aim of this paper was to review the literature on safety of mirtazapine during pregnancy and lactation.
View Article and Find Full Text PDFMirtazapine in pregnancy and lactation: data from a case series.
J Clin Psychopharmacol
April 2015
From the Departments of *Pediatrics, †Gynecology and Obstetrics, and ‡Psychiatry, Sint Lucas Andreas Hospital, VU University Medical Center, Amsterdam, the Netherlands.
Depression is a common disorder in pregnancy and associated with adverse effects for both mother and neonate. Pharmacological treatment and prevention options include mirtazapine. In a series of 56 cases, we investigated neonatal outcome after intrauterine exposure to mirtazapine and exposure through lactation in the first days postpartum.
View Article and Find Full Text PDFAntidepressants in pregnancy: a review of commonly prescribed medications.
Obstet Gynecol Surv
December 2011
Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, Duke Clinical Research Institute, Duke University, Durham, NC 27710, USA.
Unlabelled: Perinatal depression is an increasingly common comorbidity of pregnancy and is associated with adverse birth outcomes. Newer classes of antidepressants have been developed with a variety of mechanisms and improved side effect profiles. There is increasing use of these medications in reproductive-aged women.
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