The effect of a cyclone (Ami, January 2003) on drinking-water quality on the island of Vanua Levu, Fiji was investigated. Following the cyclone nearly three-quarters of the samples analysed did not conform to World Health Organisation (WHO) guideline values for safe drinking-water in terms of chlorine residual, total and faecal coliforms, and turbidity. Turbidity and total coliform levels significantly increased (up 56 and 62 per cent, respectively) from pre-cyclone levels, which was likely due to the large amounts of silt and debris entering water-supply sources during the cyclone. The utility found it difficult to maintain a reliable supply of treated water in the aftermath of the disaster. Communities were unaware they were drinking water that had not been adequately treated. Circumstances permitted this cyclone to be used as a case study to assess whether a simple paper-strip water-quality test (the hydrogen sulphide, H(2)S) kit could be distributed and used for community-based monitoring following such a disaster event to better protect public health. The H(2)S test results correlated well with faecal and total coliform results as found in previous studies. A small percentage of samples (about 10 per cent) tested positive for faecal and total coliforms but did not test positive in the H(2)S test. It was concluded that the H(2)S test would be well suited to wider use, especially in the absence of water-quality monitoring capabilities for outer island groups as it is inexpensive and easy to use, thus enabling communities and community health workers with minimal training to test their own water supplies without outside assistance. The importance of public education before and after natural disasters is also discussed.
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http://dx.doi.org/10.1111/j.0361-3666.2004.00266.x | DOI Listing |
Acta Pharm Sin B
December 2024
Key Laboratory of Drug Metabolism and Pharmacokinetics, Research Unit of PK-PD Based Bioactive Components and Pharmacodynamic Target Discovery of Natural Medicine of Chinese Academy of Medical Sciences, China Pharmaceutical University, Nanjing 210009, China.
Hydrogen sulfide (HS) is a gas signaling molecule with versatile bioactivities; however, its exploitation for disease treatment appears challenging. This study describes the design and characterization of a novel type of HS donor-drug conjugate (DDC) based on the thio-ProTide scaffold, an evolution of the ProTide strategy successfully used in drug discovery. The new HS DDCs achieved hepatic co-delivery of HS and an anti-fibrotic drug candidate named hydronidone, which synergistically attenuated liver injury and resulted in more sufficient intracellular drug exposure.
View Article and Find Full Text PDFNeuromolecular Med
January 2025
Electrophysiology Research Center, Neuroscience Institute, Tehran University of Medical Sciences, Tehran, Iran.
Chronic kidney disease (CKD) is a conceivable new risk factor for cognitive disorder and dementia. Uremic toxicity, oxidative stress, and peripheral-central inflammation have been considered important mediators of CKD-induced nervous disorders. Nitric oxide (NO) is a retrograde neurotransmitter in synapses, and has vital roles in intracellular signaling in neurons.
View Article and Find Full Text PDFSmall
January 2025
National Innovation Platform (Center) for Industry-Education Integration of Energy Storage Technology, Xi'an Jiaotong University, Xi'an, 710049, P. R. China.
As global demand for clean and sustainable energy continues to rise, fuel cell technology has seen rapid advancement. However, the presence of trace impurities like carbon monoxide (CO) and hydrogen sulfide (H₂S) in hydrogen fuel can significantly deactivate the anode by blocking its active sites, leading to reduced performance. Developing electrocatalysts that are resistant to CO and H₂S poisoning has therefore become a critical priority.
View Article and Find Full Text PDFJ Orthop Surg Res
January 2025
Kunshan First People's Hospital Joint Surgery Department, 566 Qianjin East Road, Kunshan City, Suzhou, Jiangsu Province, 215399, China.
Background: Interactions between RNA-binding proteins and RNA regulate RNA transcription during osteoporosis. Ferroptosis, a programmed cell death caused by iron metabolism, plays a vital role in osteoporosis. However, the mechanisms by which RNA-binding proteins are involved in ferroptosis during osteoporosis remain unclear.
View Article and Find Full Text PDFTheranostics
January 2025
Lab of Molecular Imaging and Translational Medicine (MITM), Engineering Research Center of Molecular and Neuro Imaging, Ministry of Education, School of Life Science and Technology, Xidian University & International Joint Research Center for Advanced Medical Imaging and Intelligent Diagnosis and Treatment, Xi'an, Shaanxi, 710126, P. R. China.
The quick and accurate detection of colorectal cancer (CRC) is essential for improving the treatment efficacy and patient survival, which nevertheless remains challenging due to low specificity and sensitivity of current CRC diagnostic approaches. Therefore, providing a robust solution for real-time and accurate tumor delineation is highly desirable. We report a novel polyacrylic acid-mediated strategy to develop the endogenous hydrogen sulfide (HS)-activated NIR-II probe DCNP@PB for specific visualization of CRC and image-guided tumor surgery.
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