AI Article Synopsis
- Two new cytotoxic compounds, methyl tortuoate A and B, were discovered from the soft coral Sarcophyton tortuosum, along with a known compound, methyl sartortuoate.
- The structures of these new compounds were determined using 2D NMR spectroscopy and confirmed through X-ray diffraction.
- Their potential effectiveness against cancer was tested in vitro on human and mouse cancer cell lines.
Article Abstract
Two new cytotoxic tetracyclic tetraterpenoids, methyl tortuoate A (1) and methyl tortuoate B (2), along with the known methyl sartortuoate (3) were isolated from the soft coral Sarcophyton tortuosum. The structures of 1 and 2 were established by spectroscopic methods, mainly on the basis of 2D NMR techniques, and were confirmed by single-crystal X-ray diffraction analysis. The cytotoxic activities of these compounds were carried out in vitro on human nasophyringeal carcinoma (CNE-2) and murine lymphocytic leukemia (P-388) tumor cell lines.
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| http://dx.doi.org/10.1021/np0400151 | DOI Listing |
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