[Effect of H2-blockers and proton pump inhibitors on intragastric acidity and intraesophageal pH in patients with gastroesophageal reflux disease].

We investigated 53 patients with GORD symptoms and a various grade (A-C according to the Los Angeles classification) of reflux oesophagitis diagnosed in the course of upper endoscopy. By using 24-hour gastric and esophageal pH-metry we investigated the antisecretory effect of single-dose morning or evening administration of famotidine, omeprazole and rabeprazole. We revealed essential superiority of single-dose morning omeprazole and rabeprazole administration in daily gastric acid release suppression and gastro-esophageal reflux prevention as compared with morning famotidine and evening omeprazole and rabeprazole administration in GORD patients.