Background: The aim of this study was to evaluate the combination of a silicon carbide-coated stent with the periprocedural use of abciximab in patients with type B2/C lesions. The study was a prospective cohort study and was conducted at the University Medical Center of Groningen.
Methods: Elective percutaneous transluminal coronary angioplasty was performed in a total of 44 patients. All had lesions with type B2/C characteristics and most were relatively small, tortuous and calcified. The involved vessel segment was stented. Silicon carbide-coated stents were used in combination with periprocedural abciximab. The main outcome measures were cardiac death, target vessel revascularization, myocardial infarction, and cerebrovascular accident.
Results: At 6 months of follow-up, only 4 patients had a major adverse cardiac event. Three patients had undergone target vessel revascularization and 1 patient had suffered from a cerebrovascular accident. Sixteen patients underwent re-angiography 6 months after the initial procedure. The average stenosis at 6 months was 15% with a minimal lumen diameter of 2.4 mm.
Conclusions: A 9% major adverse cardiac event rate and a 7% target vessel revascularization rate at 6 months in type B2/C lesions were recorded. Further investigation on the use of this specific treatment combination is warranted.
Download full-text PDF |
Source |
|---|
Publication Analysis
Top Keywords
Similar Publications
Bone screws of porous silicon carbide coated with tantalum improve osseointegration and osteogenesis in goat femoral neck fractures.
Biomed Mater
August 2021
Orthopaedic of Department, Affiliated ZhongShan Hospital of Dalian University, Dalian 116001, People's Republic of China.
Traditional metal materials, such as stainless steel and titanium (Ti) alloys, are still the gold standards for fracture fixation. However, the elastic moduli of these materials differ from that of human cortical bone, and the stress shielding effect affects fracture healing, leading to secondary fractures. Herein, a new porous Ta coated SiC (pTa-SiC) scaffold using in internal fixation devices with good mechanical and biological properties was prepared based on porous silicon carbide (SiC) scaffold and tantalum (Ta) metal.
View Article and Find Full Text PDFInterfacial Structure of Carbide-Coated Graphite/Al Composites and Its Effect on Thermal Conductivity and Strength.
Materials (Basel)
March 2021
GRINM Metal Composites Technology Co. Ltd., Beijing 101407, China.
Graphite/Al composites had attracted significant attention for thermal management applications due to their excellent thermal properties. However, the improvement of thermal properties was restricted by the insufficient wettability between graphite and Al. In this study, silicon carbide and titanium carbide coatings have been uniformly coated on the graphite by the reactive sputtering method, and Graphite/Al laminate composites were fabricated by a hot isostatic pressing process to investigate the influence on thermal conductivity and mechanical properties.
View Article and Find Full Text PDFPorous silicon carbide coated with tantalum as potential material for bone implants.
Regen Biomater
October 2020
Orthopaedic Department Affiliated ZhongShan Hospital of Dalian University, No. 6 Jiefang Street, Zhongshan District, Dalian, Liaoning 116001, China.
Porous silicon carbide (SiC) has a specific biomorphous microstructure similar to the trabecular microstructure of human bone. Compared with that of bioactive ceramics, such as calcium phosphate, SiC does not induce spontaneous interface bonding to living bone. In this study, bioactive tantalum (Ta) metal deposited on porous SiC scaffolds by chemical vapour deposition was investigated to accelerate osseointegration and improve the bonding to bones.
View Article and Find Full Text PDFMorphological Control of Silicon Carbide Deposited on Hi-Nicalon Type S Fiber Using Atmospheric Pressure Chemical Vapor Infiltration.
ACS Omega
September 2020
Department of Chemistry, University of Connecticut, Storrs, Connecticut 06269, United States.
Silicon carbide coated onto Hi-Nicalon Type S fiber is of great interest to the aerospace industry. This work focuses on tuning the reaction parameters of atmospheric pressure SiC CVI using CHSiCl to control the morphology of the coatings produced. Depth of CHSiCl from 1 to 14 cm, temperature from 1000 to 1100 °C, and flow rate of H carrier gas from 5 to 30 SCCM were examined.
View Article and Find Full Text PDFDo ultrathin strut bare-metal stents with passive coating improve efficacy in large coronary arteries? Insights from the randomized, multicenter BASKET-PROVE trials.
BMC Cardiovasc Disord
October 2019
Department of Cardiology, University Hospital Bispebjerg and Frederiksberg, DK-2400, Copenhagen, NV, Denmark.
Background: The new generation thinner-strut silicon carbide (SiC) coated cobalt chromium (CoCr) bare-metal stents (BMS) are designed to accelerate rapid endothelialisation and reduce thrombogenicity when implanted in coronary arteries. However, smaller studies suggest higher rates of symptomatic restenosis in patients receiving the newer generation BMS. We investigated the efficacy of a newer generation ultrathin strut silicon-carbide coated cobalt-chromium (CoCr) BMS (SCC-BMS) as compared to an older thin-strut uncoated CoCr BMS (UC-BMS) in patients presenting with coronary artery disease requiring stenting of large vessels (≥3.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!