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Meta-Analysis of the Association Between -2578C/A Polymorphism and Susceptibility to Type 2 Diabetic Retinopathy.
Curr Eye Res
January 2025
Fundus Disease Department, Ai'er Ophthalmology Hospital of Shangrao, Shangrao, Jiangxi, China.
Purpose: to investigate the association between vascular endothelial growth factor (-2578C/A polymorphism and susceptibility to type 2 diabetic retinopathy (T2DR) by meta-analysis.
Methods: According to the search strategy, Four databases were retrieved to identify the literature on the relationship between polymorphism and the risk of T2DR from inception to July 2024. Stata 15.
The accumulation of harmful genes within the ROH hotspot regions of the Tibetan sheep genome does not lead to genetic load.
BMC Genomics
January 2025
Key Laboratory of Animal Genetics and Breeding on Tibetan Plateau, Ministry of Agriculture and Rural Affairs, Lanzhou Institute of Husbandry and Pharmaceutical Sciences of Chinese Academy of Agricultural Sciences, Lanzhou, 730050, China.
Background: Prolonged natural selection and artificial breeding have contributed to increased uniformity within the Tibetan sheep population, resulting in a reduction in genetic diversity and the establishment of selective signatures in the genome. This process has led to a loss of heterozygosity in specific genomic regions and the formation of Runs of Homozygosity (ROH). Current research on ROH predominantly focuses on inbreeding and the signals of selection; however, there is a paucity of investigation into the genetic load and selective pressures associated with ROH, both within these regions and beyond.
View Article and Find Full Text PDFPhylogenetic relationships and genetic diversity of Tunisian maize landraces.
PLoS One
January 2025
Misión Biológica de Galicia (Spanish National Research Council, CSIC) Apdo 28, Pontevedra, Spain.
Based on history, maize was first introduced into Tunisia and northern Africa, at large, from the south of Spain. Several subsequent introductions were made from diverse origins, generating new landraces by recombination and selection for adaptation to arid environments. This study aimed to investigate the phylogenetic relationships among Tunisian maize landraces with possible sources of introduction from neighboring countries.
View Article and Find Full Text PDFHighly Potent New Probiotic Strains from Traditional Turkish Fermented Foods.
Curr Microbiol
January 2025
Department of Nanotechnology Engineering, Abdullah Gul University, Kayseri, Türkiye.
Traditional Turkish fermented foods like boza, pickles, and tarhana are recognized for their nutritional and health benefits, yet the probiotic potential of lactic acid bacteria (LAB) strains isolated from them remains underexplored. Sixty-six LAB strains were isolated from fermented foods using bacterial morphology, Gram staining, and catalase activity. The isolates were differentiated at strain level by RAPD-PCR (Random Amplification of Polymorphic DNA-Polymerase Chain Reaction) and twenty-five strains were selected for further evaluation of acid and bile salt tolerance.
View Article and Find Full Text PDFDefining a genetic background for bamboo spine and Axial spondyloarthritis.
Joint Bone Spine
January 2025
Marmara University, Institute of Health Sciences, Department of Medical Biology and Genetics, Istanbul, Turkey; Department of Medical Biology, School of Medicine, Marmara University, Istanbul, Turkey. Electronic address:
Objective: Bamboo spine is the most severe complication of Axial spondyloarthritis (AxSpA). This study aims to address whether haplotypes of endoplasmic reticulum aminopeptidase (ERAP)1 and ERAP2 single nucleotide polymorphisms (SNPs), previously associated with AXSPA, are associated with the development of bamboo spine in an AxSpA cohort.
Methods: The study included 192 patients with AxSpA followed in MARS (MARmara Spondyloarthritis) clinic and fulfilling the modified New York criteria.
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