We propose a novel principle of velocity mass analysis of a micro-particle using magnetophoretic force. The new method can determine the mass of a particle from its magnetophoretic velocity change in a high magnetic field gradient in a low viscous medium such as air. In the present study, the new principle was demonstrated by the magnetophoretic acceleration of an aqueous manganese(II) chloride micro-droplet and the deceleration of a water micro-droplet in the atmosphere. The observed velocity change was analyzed taking into account the mass of the droplet through the acceleration term of the equation of motion. The experimental results proved that the inertia force in the magnetophoretic velocity of a micro-particle could be detected in air. The present method provided an innovative mass analysis method without any ionization of the sample.
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http://dx.doi.org/10.2116/analsci.20.1483 | DOI Listing |
ACS Appl Bio Mater
June 2024
Chair of Bioseparation Engineering, TUM School of Engineering and Design, Technical University of Munich, Boltzmannstraße 15, 85748 Garching, Germany.
Magnetic separation is a promising alternative to chromatography for enhancing the downstream processing (DSP) of monoclonal antibodies (mAbs). However, there is a lack of efficient magnetic particles for successful application. Aiming to fill this gap, we demonstrate the suitability of bare iron oxide nanoparticles (BION) with physical site-directed immobilization of an engineered Protein A affinity ligand (rSpA) as an innovative magnetic material.
View Article and Find Full Text PDFSoft Matter
March 2024
Department of Chemical and Biomedical Engineering, FAMU-FSU College of Engineering, Tallahassee, FL, 32310, USA.
We report a numerical investigation of the magnetophoresis of solutions containing paramagnetic metal ions. Using a simulated magnetic field of a superconducting magnet and the convection-diffusion model, we study the transport of transition metal salts through a porous medium domain. In particular, through a detailed comparison of the numerical results of magnetophoretic velocity and ion concentration profiles with prior published experiments, we validate the model.
View Article and Find Full Text PDFLangmuir
April 2023
School of Chemical Engineering, Universiti Sains Malaysia, 14300 Nibong Tebal, Penang, Malaysia.
The possible magnetophoretic migration of iron oxide nanoparticles through the cellulosic matrix within a single layer of paper is challenging with its underlying mechanism remained unclear. Even with the recent advancements of theoretical understanding on magnetophoresis, mainly driven by cooperative and hydrodynamics phenomena, the contributions of these two mechanisms on possible penetration of magnetic nanoparticles through cellulosic matrix of paper have yet been proven. Here, by using iron oxide nanoparticles (IONPs), both nanospheres and nanorods, we have investigated the migration kinetics of these nanoparticles through grade 4 Whatman filter paper with a particle retention of 20-25 μm.
View Article and Find Full Text PDFJ Colloid Interface Sci
March 2023
State Key Laboratory of Bioelectronics, School of Biological Science and Medical Engineering, Southeast University, Nanjing 210096, PR China. Electronic address:
J Colloid Interface Sci
January 2023
Departamento de Física Aplicada, Universidade de Vigo, 36310 Vigo, Spain; CINBIO, Universidade de Vigo, 36310 Vigo, Spain. Electronic address:
Elongated nanostructures to be remotely and magnetically propelled in biologically relevant media, have gained attention as offering themselves as effective tools or carriers in theragnostics applications. However, the magnetic actuation associated remains challenging due to the lack of mechanical information in the media of interest, taking into account biophysical or biomedical purposes. In this study, we detail the magnetic actuation of magnetically propelled chained nanocomposites considering their dynamics, in which their velocity can be modulated in terms of the viscosity of the medium considered, given a magnetic field gradient.
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