Toll-like receptor 4 (TLR-4) is required for detection of Gram negative bacterial infections by binding lipopolysaccharide (LPS) and for the initiation of inflammatory signaling. Recent studies have demonstrated that a nonsynonymous single-nucleotide polymorphism (Asp299Gly, A+896G) is associated with decreased endotoxin responsiveness and poor outcomes from sepsis. We show that human carriers of this polymorphism show no deficit in LPS induced peripheral blood mononuclear cell (PBMC) mitogen-activated protein kinase (MAPK) activity, no reduction in sensitivity to endotoxin, and variable differences in whole-blood inflammatory cytokine production. These results indicate that this mutation is not a primary determinant of human endotoxin sensitivity.
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TLR4 and TNF-α single nucleotide polymorphisms in patients with brucellosis: Association with infection complications.
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Department of Medicine and Research Laboratory of Internal Medicine, National Expertise Centre of Greece in Autoimmune Liver Diseases, General University Hospital of Larissa, Larissa 41110, Greece.
Objectives: To investigate associations of the carriage of single nucleotide polymorphisms (SNPs) of proteins involved in the immune response of patients with brucellosis.
Methods: A case control study of patients with brucellosis upon WHO criteria. Blood genomic analysis was performed by RFLP- PCR for the detection of SNPs: i) at promoters -376 G > A (rs1800750); -308 G > A (rs 1,800,629); -238 G > A (rs361525) of the TNF gene, ii) at -896 A > G Asp299Gly (rs4986790) and -1196 C > T Thr399Ile (rs4986791) positions of the TLR-4 gene.
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Intern Emerg Med
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Division of Geriatric Medicine, Department of Internal Medicine, Cerrahpasa Medical Faculty, Istanbul University-Cerrahpasa, Cerrahpaşa Mahallesi Kocamustafapaşa Caddesi No:34/E Fatih, Istanbul, Turkey.
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View Article and Find Full Text PDFTLR4 polymorphism and haplotype are associated with obesity and lipid profile in young population: a pilot study.
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Laboratorio de Investigación en Microbiología. Facultad de Ciencias Químico Biológicas, Universidad Autónoma de Guerrero, México. Av. Lázaro Cárdenas S/N, Ciudad Universitaria Sur Col. Haciendita, C. P. 39090, Chilpancingo, Guerrero, México.
Background: The single nucleotide polymorphisms in the TLR4 gene can decrease or increase the response to lipopolysaccharide, increasing the susceptibility to inflammatory diseases, affecting the expression or receptor function by inducing a low-grade chronic inflammatory response.
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Department of Animal Science and Biotechnology, Kyungpook National University, Sangju 37224, Korea.
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Beijing Union University, Beijing 100101.
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