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Alterations of subcortical structural volume in pediatric bipolar disorder patients with and without psychotic symptoms.

Psychiatry Res Neuroimaging

January 2025

Department of Child Psychology, The Children's Hospital, National Clinical Research Center for Child Health, Zhejiang University School of Medicine, National Children's Regional Medical Center, Hangzhou, Zhejiang, China. Electronic address:

Background: Pediatric bipolar disorder (PBD) with psychotic symptoms may predict more severe impairment in social functioning, but the underlying biological mechanisms remain unclear. The aim of this study was to investigate alterations in subcortical structural volume in PBD with and without psychotic symptoms.

Methods: We recruited 24 psychotic PBD (P-PBD) patients, 24 non-psychotic PBD (NP-PBD) patients, and 18 healthy controls (HCs).

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Introduction: The objective of this study was to compare the dental and skeletal changes promoted by the miniscrew-anchored cantilever and pendulum appliance for Class II correction.

Methods: This retrospective study involved 52 patients with Class II malocclusion divided into 2 groups according to the treatment received: the miniscrew group (MG) with 23 patients (14 females and 9 males; mean initial age of 12.42 years) treated using the miniscrew-anchored cantilever, and the pendulum group (PG) with 29 patients (21 females and 8 males; mean initial age of 13.

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Objective: The pulvinar nucleus of the thalamus has extensive cortical connections with the temporal, parietal, and occipital lobes. Deep brain stimulation (DBS) targeting the pulvinar nucleus, therefore, carries the potential for therapeutic benefit in patients with drug-resistant posterior quadrant epilepsy (PQE) and neocortical temporal lobe epilepsy (TLE). Here, we present a single-center experience of patients managed via bilateral DBS of the pulvinar nucleus.

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Soil reinforcement is one of the techniques used to enhance the engineer characteristics of the soil. Various techniques can be employed to stabilise problematic soils, such as soft clay. These include the utilisation of portland cement, lime, fly ash, ground freezing, jet grouting, prefabricated vertical drains, and thermal approaches.

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Number and space are inherently related. Previous research has provided evidence that numbers are aligned to a so-called "mental number line", which is malleable and affected by cultural factors mostly linked to literacy-related habits. However, preverbal humans and non-human animals also map numerosities into space, in a consistent left-to-right direction.

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