The localization and activity of macrophage migration inhibitory factor (MIF) was investigated in the interhemal region of the noninvasive, diffuse, folded epitheliochorial placenta and in the nonpregnant uterus of the pig. MIF, a proinflammatory cytokine with many actions on macrophages and monocytes, may play an important role in materno-fetal immuno-tolerance during placental establishment, modulation, and growth. Immunohistochemical staining with anti-human MIF polyclonal antibodies was carried out on placental sections from 11 stages of gestation (16-95 days postcoitus) and on nonpregnant uterus at 13 days postestrus. Western blot analysis confirmed the specificity of the anti-human MIF polyclonal antibodies on pig tissues. MIF staining was intense in both the trophoblast and maternal epithelium in the early stages; in the later stages, it decreased dramatically in the maternal epithelium but remained high in the trophoblast. The uterine glands showed immunoreactivity at all stages, and the maternal and fetal epithelial linings of the areolar cavity showed high reactivity at Day 25. The vasculature also showed staining for MIF, and an intense to moderate staining was shown in the nonpregnant uterus, mostly in the surface and glandular epithelium. The high activity of MIF in the maternal and fetal tissues throughout placentation and its expression in the nonpregnant uterus indicate a regulatory role for MIF during embryo receptivity and epitheliochorial placentation.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1095/biolreprod.104.029058 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Relationship between chronic endometritis and fallopian tube obstruction and its influence on pregnancy outcome after fallopian tubal recanalization.
Ther Adv Reprod Health
December 2024
Department of Obstetrics and Gynecology, Beijing Shijitan Hospital, Capital Medical University, Beijing 100038, China.
Background: Chronic endometritis (CE), frequently asymptomatic, is associated with female infertility. Fallopian tube obstruction (FTO) is also one of the factors contributing to female infertility. More than 90% of cases of proximal FTO can be successfully treated after fallopian tubal recanalization (FTR) and the spontaneous pregnancy rate of treated women after FTR is only about 30%.
View Article and Find Full Text PDFA case report of adenomyosis-induced spontaneous rupture in an unscarred and unpregnant uterus.
Medicine (Baltimore)
December 2024
Department of Ultrasound, Tongde Hospital of Zhejiang Province, Hangzhou, China.
Rationale: Spontaneous uterine rupture, although rare, is a life-threatening obstetric emergency with a high maternal and fetal mortality rate. It can occur without warning, leading to severe complications, including hemorrhage, shock, and fetal demise. The risk factors contributing to uterine rupture are diverse and include a history of uterine surgery (such as cesarean section), trauma to the uterus, abnormal uterine contractions during labor, and underlying conditions like adenomyosis.
View Article and Find Full Text PDFDoes COVID-19 reduce anti-Mullerian hormone levels in women of reproductive age in late periods of infection?
J Turk Ger Gynecol Assoc
December 2024
Clinic of Obstetrics and Gynecology, University of Health Sciences Turkey, Bakırköy Dr. Sadi Konuk Training and Research Hospital, İstanbul, Turkey.
Objective: The question of whether severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) infection influences ovarian function and oocyte quality has arisen as angiotensin converting enzyme-2 receptors, which facilitates viral infection, are found on reproductive system tissues, including the vagina, placenta, uterus, and ovaries. The primary objective of this prospective study was to evaluate the impact of SARS-CoV-2, on ovarian function, with a focus on anti-Mullerian hormone (AMH) and acute phase reactant levels in patients well after recovery from coronavirus disease-2019 (COVID-19).
Material And Methods: This prospective cohort study was conducted in the department of obstetrics and gynecology at a single center between October 2020 and June 2021.
Revisiting the follicle-stimulation hormone receptor expression and function in human myometrium and adipose tissue.
Mol Med
December 2024
Institute of Biomedicine, Research Centre for Integrative Physiology and Pharmacology, University of Turku, Turku, 20520, Finland.
Article Synopsis
- The study investigates the expression and functionality of follicle-stimulating hormone receptor (FSHR) in human myometrium (uterine muscle) and adipose tissue (fat) during both non-pregnant and pregnant states, as well as its connection to uterine activity and fat thermogenesis.
- Using various methods to evaluate FSHR expression and treatment effects, the researchers found no FSHR expression in these tissues, contradicting prior studies.
- The results indicate that FSHR signaling does not play a role in regulating uterine contraction or influencing adipose tissue activities, casting doubt on previous assumptions about FSHR's functionality in these areas
Time-Dependent Material Properties and Composition of the Nonhuman Primate Uterine Layers Through Gestation.
bioRxiv
November 2024
Department of Mechanical Engineering, Columbia University, New York, NY, USA.
Article Synopsis
- The study examines the importance of the uterus and its biomechanical properties in supporting healthy pregnancies, identifying how alterations can lead to complications.
- Researchers analyzed the nonhuman primate (NHP) uterus at different stages of pregnancy to understand its micro-mechanical properties and composition.
- Key findings showed distinct stiffness and hydration levels in the endometrium-decidua layer, with NHP uterine properties closely resembling human data, affirming NHPs as useful models for human uterine biomechanical studies.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!