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Multimodal integration using a machine learning approach facilitates risk stratification in HR+/HER2- breast cancer.
Cell Rep Med
January 2025
Key Laboratory of Breast Cancer in Shanghai, Department of Breast Surgery, Fudan University Shanghai Cancer Center, Department of Oncology, Shanghai Medical College, Fudan University, Shanghai 200032, P.R.China. Electronic address:
Hormone receptor-positive (HR+)/human epidermal growth factor receptor 2-negative (HER2-) breast cancer is the most common type of breast cancer, with continuous recurrence remaining an important clinical issue. Current relapse predictive models in HR+/HER2- breast cancer patients still have limitations. The integration of multidimensional data represents a promising alternative for predicting relapse.
View Article and Find Full Text PDFCase report: Illustrating associated malignancies in Paget's disease using contrast-enhanced mammography.
Front Oncol
January 2025
Breast Imaging Division, European Institute of Oncology (IEO), Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), Milan, Italy.
Introduction: The following presentation explores the diagnostic potential of Contrast-Enhanced Mammography (CEM) in evaluating and managing Paget's Disease (PD) of the breast, particularly as an alternative or complementary tool to Magnetic Resonance Imaging (MRI) in cases where MRI is contraindicated or inconclusive.
Clinical Cases: Two clinical cases of PD diagnosed at our Breast Imaging Division between January and May 2024 were analyzed using CEM. These cases involved imaging techniques, including Digital Mammography (DM), Breast Ultrasound (US), MRI and CEM, alongside histopathological confirmation through nipple-areolar complex (NAC) punch biopsies.
Robust Automated Harmonization of Heterogeneous Data Through Ensemble Machine Learning: Algorithm Development and Validation Study.
JMIR Med Inform
January 2025
Department of Biostatistics & Bioinformatics, Duke University, Durham, NC, United States.
Background: Cohort studies contain rich clinical data across large and diverse patient populations and are a common source of observational data for clinical research. Because large scale cohort studies are both time and resource intensive, one alternative is to harmonize data from existing cohorts through multicohort studies. However, given differences in variable encoding, accurate variable harmonization is difficult.
View Article and Find Full Text PDFNurses' Attitudes Toward Holistic and Complementary Medicine in Pain Management.
Pain Manag Nurs
January 2025
Aksehir KadirYallagoz Health School, Selcuk University, Aksehir, Konya, Turkiye.
Background: The effects of nurses' attitudes toward complementary and alternative medicine (CAM) in pain management in terms of safety and quality of life are important. Nurses turn to a CAM approach to deal with pain problems.
Aim: This study aimed to investigate nurses' attitudes toward CAM and to determine their sociodemographic and pain-related characteristics.
The evidence to date: implications of l-ascorbic acid in the pathophysiology of aging.
J Physiol Sci
January 2025
Molecular Regulation of Aging, Tokyo Metropolitan Institute for Geriatrics and Gerontology, 173-0015, Tokyo, Japan.
L-Ascorbic acid, commonly known as vitamin C, has been used not only for disease prevention and in complementary and alternative medicine, but also for anti-aging purposes. However, the scientific evidence is not yet sufficient. Here, we review the physiological functions of vitamin C and its relationship with various pathological conditions, including our previous findings, and discuss the prospects of its application in healthy longevity.
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