Download full-text PDF |
Source |
|---|
Publication Analysis
Top Keywords
Similar Publications
Chimerism analysis by ABO blood group genotyping with digital droplet PCR.
Int J Hematol
December 2024
Clinical Research Institute, Kanagawa Children's Medical Center, Yokohama, Kanagawa, Japan.
Objective: Chimerism analysis is an important post-transplant assessment for allogeneic hematopoietic stem cell transplant (HCT) recipients. Although various chimerism analysis techniques are already established, they are limited in terms of sensitivity, versatility, and turnaround time. Our objective was to develop a digital droplet polymerase chain reaction (ddPCR) assay for chimerism analysis using ABO gene polymorphisms as markers.
View Article and Find Full Text PDFMicrochimerism: The mystery of multiple DNA and its implications in forensic sciences.
Forensic Sci Int
December 2024
Department of Science, Institute of Forensic Sciences and Legal Medicine, Istanbul University-Cerrahpaşa, Istanbul, Turkey. Electronic address:
Microchimerism (MC) refers to the presence of small amounts of foreign cells or DNA in the tissues or circulation of an individual. It generally occurs through mother-fetus interaction, twin pregnancies, and intergenerational transmission. MC is influenced by genetic and environmental factors such as toxic conditions, immunological suppression, and various diseases (influenza, COVID-19, etc.
View Article and Find Full Text PDFMaintenance strategies for relapse prevention and treatment.
Hematology Am Soc Hematol Educ Program
December 2024
Hematology and Oncology, Department of Medicine, University of Pittsburgh, Pittsburgh, PA.
Posttransplant relapse is the most significant challenge in allogeneic stem cell transplantation (alloSCT). Posttransplant interventions, in conjunction with optimal conditioning regimens and donor selection, are increasingly supported by evidence for their potential to prolong patient survival by promoting antileukemia or graft-versus-leukemia effects. Our review begins by highlighting the current evidence supporting maintenance therapy for relapse prevention in acute myeloid leukemia and acute lymphocytic leukemia.
View Article and Find Full Text PDFCase report: A novel homozygous variant in a patient with severe combined immunodeficiency and persistent COVID-19.
Front Immunol
November 2024
Laboratory of Genomic Medicine, Center of Experimental Research, Hospital de Clínicas de Porto Alegre (HCPA), Porto Alegre, Rio Grande do Sul, Brazil.
Article Synopsis
- Inborn errors of immunity (IEI) involve various disorders that can be hard to diagnose early, as shown in a Brazilian patient with severe combined immunodeficiency (SCID) diagnosed at 6 months old due to multiple infections.
- After undergoing hematopoietic stem cell transplantation (HSCT), the patient experienced recurrent infections and tested positive for SARS-CoV-2 multiple times over six months.
- Whole exome sequencing revealed a damaging genetic variant in the Janus Kinase 3 (JAK3) gene, suggesting its role in disrupting protein function and contributing to SCID's pathogenesis.
Thrombopoietin mimetic therapy alleviates radiation-induced bone marrow vascular injury in a bone marrow transplant mouse model.
Front Oncol
October 2024
Department of Radiation Oncology, City of Hope National Medical Center, Duarte, CA, United States.
Article Synopsis
- There is a need for therapies to address bone marrow dysfunction and organ toxicity following myeloablative injury during bone marrow transplantation (BMT), associated with damage to the vascular endothelium and other organs.* -
- The study aimed to assess the effects of the thrombopoietin mimetic drug JNJ-26366821 (TPOm) on the recovery of bone marrow vascularity in mice undergoing BMT after receiving radiation conditioning.* -
- Results indicated that while donor chimerism remained similar in TPOm and control-treated mice, the treatment enhanced bone marrow vasculature regeneration, showing dose-dependent improvements in microvascular density and other vascular metrics on day 14 post-BMT.*
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!