[Von Willebrand factor and thrombomodulin as markers of endothelial cell functions in children with chronic viral hepatitis].

Introduction: Vascular endothelial cells play an important role in haemostasis. Similar to hepatocytes they synthesise many substances taking part in blood clotting and fibrinolysis.

Objective: The aim of the study was the evaluation of markers of endothelial cells: von Willebrand factor (vWf) and thrombomodulin (TM) in children with chronic viral hepatitis.

Material And Methods: VWf and TM levels were measured using ELISA method. The examined group consists of 105 children with chronic viral hepatitis aged 2 to 18 years.

Results: The concentrations of vWf and TM were significantly higher in chronic viral hepatitis compared to controls. The values of TM were higher in chronic viral hepatitis B in comparison to hepatitis C and higher in boys than in girls. The markers of endothelial cells do not depend on the degree of inflammation and fibrosis.

Conclusion: Increased levels of vWf and TM suggest stimulation of endothelial cells in children with chronic viral hepatitis B and C.