AI Article Synopsis
- Researchers studied how leptin affects respiration rates in mouse skeletal muscle and its interaction with metabolism using specific enzymes like PI3K and AMPK.
- *The findings indicate that leptin boosts heat production in muscle by promoting a cycle between fat production and fat burning, which relies on both PI3K and AMPK signaling pathways.
- *This process helps prevent excessive fat buildup in skeletal muscle, offering a new understanding of how leptin contributes to metabolic health.
Article Abstract
We report here studies that integrate data of respiration rate from mouse skeletal muscle in response to leptin and pharmacological interference with intermediary metabolism, together with assays for phosphatidylinositol 3-kinase (PI3K) and AMP-activated protein kinase (AMPK). Our results suggest that the direct effect of leptin in stimulating thermogenesis in skeletal muscle is mediated by substrate cycling between de novo lipogenesis and lipid oxidation, and that this cycle requires both PI3K and AMPK signaling. This substrate cycling linking glucose and lipid metabolism to thermogenesis provides a novel thermogenic mechanism by which leptin protects skeletal muscle from excessive fat storage and lipotoxicity.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.febslet.2004.10.066 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!