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Use of Haloperidol in Companion Psittacine Birds: 19 Cases (2012-2022).
J Avian Med Surg
January 2025
Department of Surgical Sciences, School of Veterinary Medicine, University of Wisconsin-Madison, Madison, WI 53706, USA,
The antipsychotic medication haloperidol has been used for many years in avian medicine as a pharmacologic therapy for refractory feather destructive behavior in pet parrots. However, despite its common use, there are no published studies evaluating its efficacy and adverse effects in psittacine birds. The goal of this study was to report the signalment, clinical presentation, dosing regimen, response to therapy, and adverse effects of companion psittacine birds prescribed oral haloperidol therapy at a single veterinary referral hospital.
View Article and Find Full Text PDFAdvanced Drug Delivery Technologies for Enhancing Bioavailability and Efficacy of Risperidone.
Int J Nanomedicine
December 2024
Department of Pharmaceutical Technology, Faculty of Pharmaceutical Sciences, Burapha University, Chonburi, Thailand.
Multidisciplinary research has been conducted on novel drug delivery technologies to maximize therapeutic advantages while curtailing undesirable reactions. Drugs under BCS Class II often have a low bioavailability because the dissolution phase limits the absorption efficiency. In this review, risperidone was used as a pharmacological model to examine the impact of solubility enhancement at the primary administration site for such pharmaceuticals.
View Article and Find Full Text PDFPharmacologic prophylaxis of postoperative delirium in elderly patients: A network meta-analysis of randomized controlled trials.
J Psychiatr Res
January 2025
Institute of Psychiatry, Psychology and Neuroscience, King's College London, UK; Mind-Body Interface Research Center (MBI-Lab), China Medical University Hospital, Taichung, Taiwan; College of Medicine, China Medical University, Taichung, Taiwan; An-Nan Hospital, China Medical University, Tainan, Taiwan. Electronic address:
Article Synopsis
- The study addresses the high rates of postoperative delirium (POD) in elderly patients and seeks to evaluate the effectiveness of various pharmacological interventions to prevent it.
- A network meta-analysis was performed on 44 randomized controlled trials (RCTs) with 11,178 patients, focusing on the incidence of POD and tolerability of treatments.
- Results showed that atypical antipsychotics were the most effective in reducing delirium, while no significant differences were found in dropout rates or all-cause mortality among the treatment groups compared to placebo.
Effect of prophylactic perphenazine on delirium after extubation in severe acute pancreatitis.
Eur J Med Res
November 2024
Department of Emergency, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, No. 197, Ruijin er Road, Huangpu District, Shanghai, 200025, China.
Article Synopsis
- Severe acute pancreatitis (SAP) can lead to delirium after invasive mechanical ventilation (IMV), impacting patient recovery negatively.
- A study of 40 SAP patients found that prophylactic use of perphenazine reduced delirium incidence from 22.5%, highlighting its potential benefit.
- Fentanyl use was identified as a risk factor for delirium, and patients with delirium experienced longer hospital stays compared to non-delirium patients.
Drug-induced parkinsonism: diagnosis and treatment.
Expert Opin Drug Saf
December 2024
Parkinson's Disease Center and Movement Disorders Clinic, Department of Neurology, Baylor College of Medicine, Houston, TX, USA.
Introduction: Drug-induced parkinsonism (DIP) is one of the most common iatrogenic movement disorders. It is characterized by tremors, slowness of movement, and shuffling gait with postural instability, clinically indistinguishable from idiopathic Parkinson's disease. Prior exposure to antipsychotic medications or other dopamine receptor blocking agents (DRBAs) is required for the diagnosis.
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