Magne-B6 was used, together with anticonvulsive therapy, in the treatment of 25 patients with different forms of epilepsy. In all cases, psychiatric status of patients featured by depression, anxiety and some psychotic sighs. The drug was prescribed in the mean therapeutic dose during 28 days. Along with psychopathologic examination, a psychometric method, using self-rating scales for Zung anxiety and depression scale, SCL-90 and Global clinical impression (CGI) scale, was administered. Magne-B6 exerted a positive non-specific influence on patient's mental state, especially with regard to affective disorders. The positive effect of the drug emerged on 14th day of the treatment and achieved a statistically significant level to 28th day. The medication was more effective in asthenic and subdepressive syndromes, in encephalopathic syndrome the efficacy was lower. The drug was well tolerated and did not cause any side effects.
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Effect of magnesium and vitamin B6 supplementation on mental health and quality of life in stressed healthy adults: Post-hoc analysis of a randomised controlled trial.
Stress Health
December 2021
Global Medical Nutritionals, Consumer Healthcare, Sanofi-Aventis, Paris, France.
Magnesium status and vitamin B6 intake have been linked to mental health and/or quality of life (QoL). In an 8-week Phase IV randomised controlled study in individuals with low magnesemia and severe/extremely severe stress but who were otherwise healthy, greater stress reduction was achieved with magnesium combined with vitamin B6 than with magnesium alone. We present a previously unreported secondary analysis of the effect of magnesium, with and without vitamin B6, on depression, anxiety, and QoL.
View Article and Find Full Text PDFSuperiority of magnesium and vitamin B6 over magnesium alone on severe stress in healthy adults with low magnesemia: A randomized, single-blind clinical trial.
PLoS One
May 2019
Clinical Pharmacology Department, CHU, Université Clermont Auvergne, Clermont-Ferrand, France.
Article Synopsis
- The study investigates the effects of magnesium combined with vitamin B6 on stress reduction in adults with low magnesium levels.
- Both magnesium-vitamin B6 and magnesium alone significantly decreased perceived stress, with no notable differences in overall effectiveness between the two groups.
- However, individuals with higher baseline stress levels showed a greater improvement with the combination treatment, indicating potential benefits for those experiencing severe stress.
[Very low magnesium levels in red blood cells as a significant factor in the etiopathogenesis of borderline disorders].
Zh Nevrol Psikhiatr Im S S Korsakova
April 2016
Ivanovo State Medical Academy, Ivanovo, Russia, RSC 'Neurobiology of Trace Element Institute for UNESCO, Moscow, Russia.
Aim: Basic studies indicate magnesium deficiency as one of the important, but often neglected, risk factors aggravating the course of borderline disorders (BD). A clinical verification of this notion has been conducted.
Material And Methods: Authors studied 62 patients with BD, aged 25-65 years, of inpatient and outpatient settings.
[Experimental evidence of magnesium salts for treatment of calcium oxalate nephrolithiasis in an animal model based on sodium oxalate and a cyclooxygenase 2 selective inhibitor].
Patol Fiziol Eksp Ter
September 2013
Volgograd State Medical University, Volgograd, Russia
The purpose of present study was to investigate influence of magnesium (Mg) salts (Mg L-aspartate, Mg chloride) and their combinations with pyridoxine on development of calcium-oxalate nephrolithiasis induced by sodium oxalate (3% diet weight) and celecoxib (100 mg per kg of bodyweight) according to B.C. Jeong et al.
View Article and Find Full Text PDFThe study was aimed to evaluation the effect of different magnesium salts and their combinations with pyridoxine on a course of calcium-oxalate nephrolithiasis, which was modeled by adding the sodium oxalate (3% of weight of the diet) and selective cyclooxygenase-2 inhibitor celecoxib at a dose 100 mg/kg body weight to a diet for 4 weeks. Starting from the 2nd week of the experiment, the animals had received one of the following compounds: magnesium L-aspartate, magnesium chloride, and their combination with vitamin B6; magnesium sulfate and Magne B6 (magnesium lactate and vitamin B6) as comparators. 28 days after the start of the experiment, disorders progressed in the group receiving only celecoxib and oxalate-rich diet: the urine level of oxalate increased by 171% (p < 0,0001), crystalluria had increased (up to 105 crystals in 10 microml of urinary sediment, p < 0,0001), creatinine clearance decreased by 29%, compared to control (p = 0,087).
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