[Review of the protective effects of tumor necrosis factor inhibitors in rheumatoid arthritis].

Rev Med Suisse Romande

Arthritis & Musculoskeletal Clinical Research Center, Department of Medicine, Brigham & Women's Hospital, Boston, USA.

Published: September 2004

Rheumatoid arthritis (RA) is a chronic in-flammatory disease with progressive joint damage, generally considered irreversible. A more aggressive therapeutic approach is promoted. Progression of joint damage, gradual functional disability and rate of mortality are lowered by disease modifying antirheumatic drugs (DMARD). Among these, we discuss the relative role of TNF inhibitors and their efficacy on preventing radiographic progression of joint damage. We also touch on the notion of a therapeutic window of opportunity early in the course of RA, as early initiation of aggressive treatment seems to provide a sustained benefit on radiographic progression.

Download full-text PDF

Source

Publication Analysis

Top Keywords

joint damage
12
progression joint
8
radiographic progression
8
[review protective
4
protective effects
4
effects tumor
4
tumor necrosis
4
necrosis factor
4
factor inhibitors
4
inhibitors rheumatoid
4

Similar Publications

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!