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Basic Science and Pathogenesis.
Alzheimers Dement
December 2024
Nova Southeastern University, Fort Lauderdale, FL, USA.
Background: Cerebral amyloid angiopathy (CAA), characterized by the accumulation of amyloid protein in the cerebral vasculature, is highly prevalent in Alzheimer's disease (AD) patients and, on its own, increases the risk of hemorrhagic stroke, cognitive impairment, and dementia. Currently, there are no effective ways to treat or prevent CAA. Ketogenic diet (KD), characterized by high-fat, low-carbohydrate, and moderate amounts of protein consumption, has gained considerable attention in recent years for its potential therapeutic use in patients with neurodegenerative diseases, including Alzheimer's disease.
View Article and Find Full Text PDFRedefining Diabetes Care: Evaluating the Impact of a Carbohydrate-Reduction, Health Coach Approach Model in New Zealand.
J Diabetes Res
January 2025
Human Potential Centre, Faculty of Health and Environmental Sciences, Auckland University of Technology, Auckland, New Zealand.
This study explores a novel healthcare model employed in the primary care setting integrating a carbohydrate-reduction dietary approach and health coaching for managing prediabetes (PD) and Type 2 diabetes (T2D) in New Zealand. Using qualitative methods, we conducted focus groups with 46 patients and individual interviews with health coaches and general practitioners across two regions. Five major themes emerged from inductive thematic analysis: reduced carbohydrate lifestyles, health coaching, implementation, empowerment, and sustainability.
View Article and Find Full Text PDFEvaluation of Energy Utilisation Efficiencies of Digestible Macronutrients in Juvenile Malabar Snapper () Reveals High Protein Requirement for Optimal Growth Using Both Factorial and Multifactorial Approaches.
Aquac Nutr
December 2024
Tropical Future Institute, James Cook University, Singapore, Singapore.
Malabar snapper () is an economically important marine fish throughout the Indo-Pacific, with an emerging aquaculture industry. Although generic marine feeds are available for production, these are not optimised for this species. Understanding energy utilisation and balance can provide insight into suitable macronutrient profiles for new species to provide a baseline for future development.
View Article and Find Full Text PDFThe Role of Diet, Additives, and Antibiotics in Metabolic Endotoxemia and Chronic Diseases.
Metabolites
December 2024
Food Functionality Research Division, Korea Food Research Institute, Jeonju 55365, Republic of Korea.
: Dietary patterns, including high-fat and high-carbohydrate diets (HFDs and HCDs), as well as non-dietary factors such as food additives and antibiotics, are strongly linked to metabolic endotoxemia, a critical driver of low-grade chronic inflammation. This review explores the mechanisms through which these factors impair intestinal permeability, disrupt gut microbial balance, and facilitate lipopolysaccharide (LPS) translocation into the bloodstream, contributing to metabolic disorders such as obesity, type 2 diabetes mellitus, and inflammatory bowel disease. : The analysis integrates findings from recent studies on the effects of dietary components and gut microbiota interactions on intestinal barrier function and systemic inflammation.
View Article and Find Full Text PDFValine Restriction Extends Survival in a Drosophila Model of Short-Chain Enoyl-CoA Hydratase 1 (ECHS1) Deficiency.
J Inherit Metab Dis
January 2025
Department of Biochemistry and Chemistry and La Trobe Institute for Molecular Science, La Trobe University, Bundoora, Victoria, Australia.
Short-chain enoyl-CoA hydratase 1 deficiency (ECHS1D) is a rare genetic disorder caused by biallelic pathogenic variants in the ECHS1 gene. ECHS1D is characterised by severe neurological and physical impairment that often leads to childhood mortality. Therapies such as protein and single nutrient-restricted diets show poor efficacy, whereas the development of new treatments is hindered by the low prevalence of the disorder and a lack of model systems for treatment testing.
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