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Efficacy of heel lifts for lower limb musculoskeletal conditions: A systematic review.
J Foot Ankle Res
June 2024
Physiotherapy Department, School of Primary and Allied Health Care, Faculty of Medicine Nursing and Health Science, Monash University, Clayton, Victoria, Australia.
Article Synopsis
- The systematic review aimed to evaluate the effectiveness and potential drawbacks of heel lifts in treating lower limb musculoskeletal conditions by comparing them to various other interventions.
- Eight trials were analyzed, involving a total of 903 participants, focusing on conditions such as Achilles tendinopathy and plantar heel pain.
- The study found limited clinically important outcomes (only 2 out of 47), highlighting the low-quality evidence for heel lifts, suggesting that the results should be interpreted with caution and may not reflect the true effect.
Differential impacts of nonsteroidal anti-inflammatory drugs on lifespan and healthspan in aged Caenorhabditis elegans.
J Appl Toxicol
October 2024
Department of Toxicology, School of Public Health, Guangxi Medical University, Nanning, Guangxi Province, China.
Article Synopsis
- Aging and age-related diseases are linked to oxidative stress and inflammation, prompting research into nonsteroidal anti-inflammatory drugs (NSAIDs) for potential lifespan extension.
- In a study with Caenorhabditis elegans, aspirin and ibuprofen were found to extend lifespan in both young and old worms by reducing reactive oxygen species (ROS) and boosting antioxidant gene expression.
- Conversely, acetaminophen and indomethacin worsened aging in older worms, suggesting they may pose risks rather than benefits for elderly individuals due to increased toxicity and oxidative stress.
Reactive oxygen species induced by indomethacin enhance accumulation of heme carrier protein 1 and hematoporphyrin accumulation and in a brain tumor model.
J Clin Biochem Nutr
May 2024
Department of Neurosurgery, Institute of Medicine, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki 305-8575, Japan.
Article Synopsis
- Photodynamic therapy (PDT) is an effective treatment for several types of cancer, but how porphyrins accumulate specifically in tumors is still unclear.
- Researchers found that the drug indomethacin (IND) enhances the production of reactive oxygen species (ROS) in cancer cells, which in turn increases the expression of a protein called heme carrier protein 1 (HCP1) that aids in transporting porphyrins.
- Tests on glioma cells and rat brain tumor models showed that pretreatment with IND significantly boosts the accumulation of porphyrins in tumor cells, leading to potential improvements in PDT effectiveness without harming normal brain tissue.
Urothelium-derived prostanoids enhance contractility of urinary bladder smooth muscle and stimulate bladder afferent nerve activity in the mouse.
Am J Physiol Regul Integr Comp Physiol
July 2024
Department of Pharmacology, University of Vermont, Burlington, Vermont, United States.
The transitional epithelial cells (urothelium) that line the lumen of the urinary bladder form a barrier between potentially harmful pathogens, toxins, and other bladder contents and the inner layers of the bladder wall. The urothelium, however, is not simply a passive barrier, as it can produce signaling factors, such as ATP, nitric oxide, prostaglandins, and other prostanoids, that can modulate bladder function. We investigated whether substances produced by the urothelium could directly modulate the contractility of the underlying urinary bladder smooth muscle.
View Article and Find Full Text PDFSyringic acid guards against indomethacin-induced gastric ulcer by alleviating inflammation, oxidative stress and apoptosis.
Biotech Histochem
April 2024
Department of Medical Pharmacology, Faculty of Medicine, Ataturk University, Erzurum, Turkey.
The purpose of this study was to evaluate the effects of syringic acid, an anti-oxidant, on indomethacin induced gastric ulcers in rats. Experimental groups were control, ulcer, ulcer treated with 20 mg/kg esomeprazole (a proton pump inhibitor that reduces acid secretion), and ulcer treated with 100 mg/kg syringic acid. Rats were pretreated with esomeprazole or syringic acid two weeks before ulcer induction.
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