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Navigating the Complexity of Stiff Person Syndrome: A Case Report and Literature Review.
Cureus
November 2024
Family Medicine, Burrell College of Osteopathic Medicine, Las Cruces, USA.
Stiff person spectrum disorder is a disease that involves a host of conditions that are associated with glutamic acid decarboxylase 65-kilodalton isoform autoantibodies. These conditions may include diabetes mellitus type 1, pernicious anemia, autoimmune leukoencephalopathy, cerebellar ataxia, and stiff-person syndrome. Clinical recognition and diagnosis of stiff person spectrum disorder are important early, as immunologic treatment options showing reliable efficacy in slowing disease progression are available.
View Article and Find Full Text PDFRisk of Esophageal and Gastric Cancer in Patients with Type 2 Diabetes Receiving Glucagon-like Peptide-1 Receptor Agonists (GLP-1 RAs): A National Analysis.
Cancers (Basel)
September 2024
Division of Gastroenterology and Hepatology, Charleston Area Medical Center, West Virginia University, Charleston, WV 25304, USA.
Article Synopsis
- - Glucagon-like peptide-1 receptor agonists (GLP-1 RAs) are popular for managing type 2 diabetes, but there's concern about their potential link to cancers, particularly pancreatic and thyroid cancers, which needs further investigation.
- - A study analyzed 2.7 million T2DM patients, comparing those on GLP-1 RAs to those not on the medication, while controlling for various health factors to measure cancer risks.
- - Results showed that T2DM patients using GLP-1 RAs had a significantly lower risk of gastric cancer (0.05% vs. 0.13%) and esophageal cancer (0.04% vs. 0.13%) after seven years
When ethnic-racial discrimination from math teachers spills over and predicts the math adjustment of nondiscriminated adolescents: The mediating role of math classroom climate perceptions.
Dev Psychol
December 2024
Crown Family School of Social Work, Policy, and Practice, University of Chicago.
Ethnic-racial discrimination is a pernicious experience that affects discriminated adolescents' healthy human development, but the spillover consequences of discrimination on the nondiscriminated adolescent population are less clear. Adolescents who vicariously witness their classmates experience ethnic-racial discrimination from educators may question their educators' authority and classroom rules, and educators who perpetuate discrimination may engage in other practices that disadvantage the entire classroom. Thus, we posed three research questions: Did classmates' ethnic-racial discrimination from teachers predict adolescents' classroom adjustment outcomes (e.
View Article and Find Full Text PDFA Qualitative Analysis of a Primary Care Medical-Legal Partnership: Impact, Barriers, and Facilitators.
J Am Board Fam Med
October 2024
From the Department of Health Systems and Population Health Sciences, University of Houston Tilman J. Fertitta Family College of Medicine, Houston, TX (WL); School of Biomedical Informatics, University of Texas Health Science Center at Houston, Houston, TX (CBB); Department of Family & Community Medicine, University of Texas Health Science Center at Houston, McGovern Medical School, Houston, TX (TFN); Department of Family & Community Medicine, University of Texas Health Science Center at Houston, McGovern Medical School, Houston, TX (ALS); Department of Medicine, University of Texas Health Science Center at Houston, McGovern Medical School, Houston, TX (AH); Department of Counseling, Wake Forest University, Winston-Salem, NC (LF); University of Houston Tilman J. Fertitta Family College of Medicine, Houston, TX (PO); University of Houston Tilman J. Fertitta Family College of Medicine, Houston, TX (BMR); University of Houston Tilman J. Fertitta Family College of Medicine (SJ); Division of Kinesiology and Health; University of Wyoming College of Health Sciences; Laramie, WY Dobbins: (LG); Humana, Inc., Louisville, KY (JD); Department of Medicine and Office of Community Engagement and Health Equity; Baylor College of Medicine; Houston, TX (LW); Department of Family & Community Medicine, University of Texas Health Science Center at Houston, McGovern Medical School, Houston, TX (TM).
Background: Certain health-related risk factors require legal interventions. Medical-legal partnerships (MLPs) are collaborations between clinics and lawyers that address these health-harming legal needs (HHLNs) and have been shown to improve health and reduce utilization.
Objective: The objective of this study is to explore the impact, barriers, and facilitators of MLP implementation in primary care clinics.
Structural regression modelling of peptide based drug delivery vectors for targeted anti-cancer therapy.
Drug Deliv Transl Res
August 2024
Department of Biosciences and Bioengineering, Indian Institute of Technology Guwahati, Guwahati, 781039, Assam, India.
Drug resistance in cancer poses a serious challenge in finding an effective remedy for cancer patients, because of the multitude of contributing factors influencing this complex phenomenon. One way to counter this problem is using a more targeted and dose-limiting approach for drug delivery, rather than relying on conventional therapies that exhibit multiple pernicious side-effects. Stability and specificity have traditionally been the core issues of peptide-based delivery vectors.
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