AI Article Synopsis
- Peripheral blood progenitor cells (PBPCs) are increasingly utilized for allogeneic transplantation, with granulocyte colony-stimulating factor (G-CSF) being the main agent for mobilization.
- Despite the mobilization process being generally safe, there have been reports of adverse effects, including rare severe incidents.
- The authors discuss a specific case of spontaneous splenic rupture in a donor who underwent PBPC mobilization, analyze the relevant literature on this event, and address concerns about donor safety.
Article Abstract
Peripheral blood progenitor cells (PBPCs) are now widely used as a source of progenitor cells for allogeneic transplantation. Recombinant human granulocyte colony-stimulating factor is used to mobilize PBPCs for collection by leukapheresis. Although side effects of mobilization are generally benign, adverse effects have been reported. The authors present a case of spontaneous splenic rupture, without splenomegaly, in a parental donor undergoing PBPC mobilization, review the literature regarding this adverse event, and explore issues regarding donor safety.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1097/00043426-200411000-00015 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Accessory splenic infarction presenting as acute abdominal pain: A case report.
Int J Surg Case Rep
January 2025
Emergency Medicine Department, Lebanese American University Medical Center, Beirut, Lebanon. Electronic address:
Introduction: Accessory spleens are a common anatomical variant, consisting of ectopic splenic tissue present in different locations in the peritoneal cavity. Typically asymptomatic, the presence of these tissue grows to be of clinical importance when complicated by infarction, rupture, or torsion.
Presentation Of Case: We report the case of a 36-year-old female that presented to the Emergency Department for diffuse abdominal pain and was found to have a partially ruptured splenule secondary to a venous infarct on abdominal computed tomography scan.
Acute Necrotizing Pancreatitis Leading to Hemosuccus Pancreaticus and Hemorrhagic Shock in the Setting of Decompensated Cirrhosis.
Cureus
December 2024
Department of Gastroenterology, Scripps Mercy Hospital, San Diego, USA.
Hemosuccus pancreaticus (HP) is a rare, life-threatening cause of upper gastrointestinal bleeding, often linked to chronic pancreatitis and pseudoaneurysm rupture into the pancreatic duct. However, its occurrence in acute necrotizing pancreatitis with decompensated cirrhosis is exceedingly rare and poses significant diagnostic and treatment challenges. We report a case of a 34-year-old male with decompensated alcoholic cirrhosis who developed hemorrhagic shock from HP following acute necrotizing pancreatitis.
View Article and Find Full Text PDFPregnancy with Wilson's Disease: A Case Series.
Mymensingh Med J
January 2025
Dr Mousumi Saha, Assistant Professor, Fetomaternal Medicine Subspeciality (FCPS) Course Student, Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka, Bangladesh; E-mail:
Wilson's disease is an autosomal recessive disorder that affects copper transport due to deficiency of ceruloplasmin and causes deposition of copper mainly in the liver, brain and cornea. It causes hepatic and/or neuropsychiatric manifestations. This copper deposition causes cirrhosis of the liver, encephalopathy and liver failure.
View Article and Find Full Text PDFThe Natural History of Portal Venous System Aneurysms.
J Vasc Surg Venous Lymphat Disord
December 2024
Division of Vascular Surgery, UPMC, Pittsburgh, Pennsylvania; Department of Surgery, University of Pittsburgh, Pittsburgh, Pennsylvania. Electronic address:
Background: Portal venous system aneurysms (PVA) are increasingly diagnosed on cross-sectional computed tomography (CT) imaging. However, the natural history of these aneurysms is poorly understood and reports are limited to small case series.
Methods: Terms relevant to PVA were searched in radiology reports (2010-2022) with PVA presence confirmed by manual review.
Spontaneous splenic rupture: A rare complication of concurrent malaria and dengue infections - A case report.
Int J Surg Case Rep
December 2024
School of Postgraduate Studies and Research, Amoud University, Amoud Valley, Borama 25263, Somalia.
Introduction: Spontaneous splenic rupture (SSR) is a rare, life-threatening complication, sometimes associated with infections like malaria and dengue fever. This case report details a unique presentation of SSR.
Case Presentation: A 28-year-old male in Somalia presented with fever, epigastric pain, nausea, vomiting, and body aches, consistent with malaria and dengue.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!