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Basic Science and Pathogenesis.
Alzheimers Dement
December 2024
Retromer Therapeutics, New York, NY, USA.
Genetic, cell biology and autopsied brain tissue studies indicate that deficits in the SORL1-retromer complex play a critical role in the pathogenesis of Alzheimer's disease (AD). SORL1 is an endosomal receptor that interacts with the retromer heterotrimer core complex consisting of VPS26-VPS35-VPS29. Together, SORL1-retromer regulate endosomal recycling of several AD-related cargos such as amyloid precursor protein.
View Article and Find Full Text PDFRefining cardiac resynchronization therapy: a comprehensive review on the role of advanced multimodality imaging.
Front Cardiovasc Med
December 2024
Department of Cardiology, University of Medicine and Pharmacy of Craiova, Craiova, Romania.
Cardiac resynchronization therapy (CRT) offers significant benefits in symptom alleviation, reduction of rehospitalization rates, and overall survival of patients with heart failure (HF) with reduced ejection fraction (rEF). However, despite its proven efficacy, precisely identifying suitable CRT candidates remains a challenge, with a notable proportion of patients experiencing non-response. Accordingly, many attempts have been made to enhance patient selection, and to identify the best imaging parameters to predict the response and survival after CRT implantation.
View Article and Find Full Text PDFThe In-depth Comparative Analysis of Four Large Language AI Models for Risk Assessment and Information Retrieval from Multi-Modality Prostate Cancer Work-up Reports.
World J Mens Health
December 2024
Division of Urology, Department of Surgery, Far Eastern Memorial Hospital, New Taipei, Taiwan.
Purpose: Information retrieval (IR) and risk assessment (RA) from multi-modality imaging and pathology reports are critical to prostate cancer (PC) treatment. This study aims to evaluate the performance of four general-purpose large language model (LLMs) in IR and RA tasks.
Materials And Methods: We conducted a study using simulated text reports from computed tomography, magnetic resonance imaging, bone scans, and biopsy pathology on stage IV PC patients.
Improving Thoracic Trauma Care: Locoregional Analgesia in the Intensive Care Unit.
Cureus
December 2024
Intensive Care Unit, Unidade Local Saúde Viseu Dão-Lafões, Viseu, PRT.
Article Synopsis
- Pain management for thoracic trauma patients traditionally relies on opioids, which can have significant side effects; locoregional anesthesia/analgesia (LRAA) offers a targeted alternative.
- The study analyzed 43 LRAA procedures in 33 ICU patients and found that 50% who received LRAA avoided intubation, leading to shorter ICU stays (9 vs. 13 days) and no severe complications from the LRAA techniques.
- Results indicate that early use of LRAA can enhance clinical outcomes for thoracic trauma patients, highlighting its potential but also the need for further investigation to understand its full benefits.
Are Oral Somatostatin Receptor Ligands Moving Closer to Becoming a Reality?
Clin Endocrinol (Oxf)
December 2024
Departments of Endocrinology, Leeds Centre for Diabetes & Endocrinology, Leeds Teaching Hospital NHS Trust, Leeds, UK.
With the current therapeutic modalities available to endocrinologists, control of GH and IGF-I is now possible in almost all patients with acromegaly with multi-modality therapy. Despite biochemical control of GH and IGF-I, patients with acromegaly continue to experience impaired quality of life. Although there are likely multiple factors contributing to this dissatisfaction with current medical therapies, in particular the widely utilised injectable long-acting somatostatin receptor ligands (iSRL), is a contributor.
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