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Functional pathology of neuroleptic-induced dystonia based on the striatal striosome-matrix dopamine system in humans.
J Neurol Neurosurg Psychiatry
January 2025
Research Organization of Science and Technology, Ritsumeikan University, Kyoto, Japan
Neuroleptic-induced dystonia is a source of great concern in clinical practice because of its iatrogenic nature which can potentially lead to life-threatening conditions. Since all neuroleptics (antipsychotics) share the ability to block the dopamine D-type receptors (DRs) that are highly enriched in the striatum, this drug-induced dystonia is thought to be caused by decreased striatal DR activity. However, how associations of striatal DR inactivation with dystonia are formed remains elusive.
View Article and Find Full Text PDFValidation of Parkinson's Disease Ascertainment in the Veterans Administration Electronic Medical Record.
Mov Disord
December 2024
San Francisco Veterans Affairs Health Care System, San Francisco, California, USA.
Background: Electronic medical record (EMR)-based studies hold great potential for epidemiologic investigations of Parkinson's disease (PD) causal factors and phenomenology, but diagnostic misclassification may obscure or bias inferences.
Objectives: The aims were to determine the validity of PD diagnostic codes in the Veterans Administration (VA) national electronic medical databases and develop recommendations for maximizing ascertainment accuracy.
Methods: We investigated a cohort of 146,776 veterans who utilized VA healthcare between 1999 and 2021.
Prospective Five-Year Follow-Up of Patients with Schizophrenia Suspected with Parkinson's Disease.
Parkinsons Dis
May 2022
Department of Neurology, Juntendo University School of Medicine, Tokyo, Japan.
Objective: It is difficult to distinguish patients with schizophrenia with neuroleptic-induced parkinsonism (NIP) from those with existing idiopathic Parkinson's disease when their striatal dopamine transporter uptake is reduced. There is a possibility of misdiagnosis of Parkinson's disease in patients with schizophrenia as schizophrenia with NIP, which leads to inappropriate treatment. This prospective study aimed at determining the underlying pathophysiology using detailed clinical and psychological assessments.
View Article and Find Full Text PDF[Tardive neuroleptic-induced dyskinesias].
Zh Nevrol Psikhiatr Im S S Korsakova
February 2022
Bekhterev National Medical Research Centerfor Psychiatry and Neurology, St. Petersburg, Russia.
Drugs that block dopaminergic transmission are currently widely used in the treatment of psychiatric diseases. One of the significant, common complications of therapy are tardive dyskinesias, which develop after prolonged, at least 3 months, therapy with antipsychotics and significantly reduce the quality of life of patients. Tardive dyskinesia is an extrapyramidal disorder, mainly manifested by involuntary hyperkinesis of the muscles of the face and tongue.
View Article and Find Full Text PDFBlockade of adenosine A receptors inhibits Tremulous Jaw Movements as well as expression of zif-268 and GAD65 mRNAs in brain motor structures.
Behav Brain Res
January 2022
Department of Neuropsychopharmacology, Maj Institute of Pharmacology Polish Academy of Sciences, 12 Smętna Street, 31-343, Kraków, Poland. Electronic address:
Tremor is one of the motor symptoms of Parkinson's disease (PD), present also in neuroleptic-induced parkinsonism. Tremulous Jaw Movements (TJMs) are suggested to be a well-validated rodent model of PD resting tremor. TJMs can be induced by typical antipsychotics and are known to be reduced by different drugs, including adenosine A receptor antagonists.
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