AI Article Synopsis
- The study explores the genetic factors influencing the age of menopause, focusing on specific polymorphisms in the ERalpha and CYP17 genes.
- DNA from 385 Caucasian women with natural menopause was examined to see if these gene variations impacted the age at which menopause occurred.
- Results indicated that none of the studied genetic variations had a significant association with the age at natural menopause, suggesting that these common gene variants do not influence menopausal timing.
Article Abstract
Background: Age at menopause is under strong genetic control. So far, genetic variations of only one gene, the PvuII polymorphism of the estrogen receptor alpha (ERalpha) gene, have been shown to be associated with age at onset of menopause. This study aims to investigate whether PvuII, XbaI and B-variant polymorphisms of the ERalpha gene, and the MspAI polymorphism of the cytochrome P450c17alpha (CYP17) gene are associated with age at menopause in a Dutch cohort.
Methods: DNA was isolated from urine samples of 385 Caucasian women with natural menopause and the genotypes of the four polymorphisms were determined. A questionnaire was used for background characteristics. The genotypes of PvuII, XbaI, MspAI were obtained by PCR restriction fragment length polymorphism analysis. The B-variant was determined with an allele-specific oligonucleotide hybridization method. Two-sided t-tests were performed to assess the association between the four polymorphisms and menopausal age. The PvuII and XbaI polymorphisms were analysed separately as well as in a combined score.
Results: The results show that none of the polymorphisms independently, nor the combined genotypes for PvuII and XbaI, were associated with age at natural menopause.
Conclusion: No evidence was found for a relationship between common variants of the ERalpha gene and the CYP17 gene with age at natural menopause.
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| http://dx.doi.org/10.1093/humrep/deh600 | DOI Listing |
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