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Antagonism of CD28 blocks allergic responses in the ovalbumin-induced asthmatic model mice.
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Allergen-reactive T helper (Th) 2 cells play a pivotal role in initiating asthma pathogenesis. The absence or interruption of CD28 signaling causes significant consequences for T-cell activation, leading to reduced cell proliferation and interleukin (IL)-2 production. A novel compound, Cyn-1324, exhibits a higher binding affinity to CD28 than CD80.
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Hepatocellular carcinoma (HCC) is the most prevalent form of primary liver cancer and the second leading cause of cancer-related mortality globally. Despite advancements in current HCC treatment, it remains a malignancy with poor prognosis. Therefore, developing novel treatment options for patients with HCC is urgently needed.
View Article and Find Full Text PDFcirc_0075829 regulates ferroptosis and immune escape in colon cancer cells through the miR-330-5p/TCF4 axis.
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Department of Gastrointestinal Surgery, Renmin Hospital of Wuhan University, Wuchang, Wuhan, Hubei, China.
Many lines of evidence suggest that circular RNAs (circRNAs) are closely associated with the occurrence and progression of colon cancer. The objective of this study was to investigate the regulatory effects and mechanisms of circ_0075829 on ferroptosis and immune escape in colon cancer. We utilized colon cancer cell lines and a xenograft mouse model to analyze the function of circ_0075829 in vitro and in vivo.
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Shanghai Immune Therapy Institute, Shanghai Jiao Tong University School of Medicine- Affiliated Renji Hospital, Shanghai, 200127, China.
T cell activation is accompanied by extensive changes in epigenome. However, the high-ordered chromatin organization underpinning CD8 T cell activation is not fully known. Here, we show extensive changes in the three-dimensional genome during CD8 T cell activation, associated with changes in gene transcription.
View Article and Find Full Text PDFTetramethylpyrazine promotes osteo-angiogenesis during bone fracture repair.
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Department of Hand and Foot Microsurgery, Jiangxi Careyou Shuguang Orthopedic Hospital, Jiayou Healthy City, No. 858 Fusheng Road, Xihu District, Nanchang, Jiangxi, 330002, China.
Background: Nonunion following a long bone fracture has gained a lot of attention due to the dreadful impact on the life quality of tremendous patients. Recent data have demonstrated the important involvement of angiogenesis in improving fracture healing. Tetramethylpyrazine (TMP) is an active component of Chinese herbal medicine with various biological activities including pro-angiogenesis property.
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