Objectives: Endocervical prostaglandin E2 gel administration is widely accepted mean of induction of labor in pregnancy at term. Further investigation is needed to assess its usage in pregnancy below 37 weeks' gestation. The aim of this study is to analyse the course of labor, its complications and neonatal outcome in preterm deliveries induced with endocervical dinoprostone.
Results: We conducted a retrospective study of 22 preterm deliveries induced with dinoprostone. A control group consisted of 26 pregnancies at term. The incidence of cesarean sections was comparable in both preterm and term deliveries (45 vs. 41%, p = 0.38). We found no differences in characteristics of indications of operative delivery, duration of particular stages of labor; time from dinoprostone administration to the beginning of 1st stage of labor, estimated blood loss. 1 and 5-minute Apgar scores were similar in both groups.
Conclusions: Endocervical prostaglandin E2 gel administration seems to be a safe method of induction of labor in preterm pregnancy.
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Sci Adv
December 2024
Division of Neonatology, Department of Pediatrics, Vanderbilt University Medical Center, Nashville, TN, USA.
The orientation and function of smooth muscle in the cervix may contribute to the important biomechanical properties that change during pregnancy. Thus, this study examined the three-dimensional structure, smooth muscle phenotype, and mechanical and contractile functions of the upper and lower cervix of nongravid (not pregnant) and gravid (pregnant) mice. In gravid cervix, we uncovered region-specific changes in the structure and organization of fiber tracts.
View Article and Find Full Text PDFBMC Pregnancy Childbirth
August 2024
Department of Obstetrics, Maternal and Child Health Hospital of Hubei Province, Tongji Medical College, Huazhong University of Science and Technology, No. 745, Wuluo Road, Hongshan District, Wuhan, 430070, China.
Background: Most guidelines propose inducing labor within 24 h following term (37 or more weeks of gestation) prelabor rupture of membranes (PROM). However, the exact timing for initiating induction within the 24 h period remains unknown. This study aims to comparatively assess the efficacy and safety of the use of vaginal dinoprostone within 6 h versus within 6-24 h for singleton pregnancies with PROM and an unfavorable cervix (Bishop score < 6).
View Article and Find Full Text PDFAm J Obstet Gynecol MFM
September 2024
Department of Obstetrics, Shanghai Key Laboratory of Maternal and Fetal Medicine, Shanghai First Maternity & Infant Hospital, Tongji University School of Medicine, Shanghai, PR China (X. Liu, Y. Liu, Qu, Zhao, and Ying). Electronic address:
Background: Induction of labor (IOL) with mechanical methods or pharmacological agents is used in about 20% to 30% of all pregnant women. We specialized in comparing the effectiveness and safety of dinoprostone vs transcervical Foley catheter for IOL in term pregnant women with an unfavorable cervix with adequate samples.
Objective: To compare the effectiveness and safety of dinoprostone vs transcervical Foley catheter for IOL in term pregnant women with an unfavorable cervix.
Contraception
December 2024
Family Planning Services and Research, Division of Gynecology and Gynecologic Specialties, Department of Obstetrics and Gynecology, Stanford University School of Medicine, Palo Alto, CA, United States.
Objectives: This study aimed to compare cervical preparation with transcervical balloon to osmotic dilators for second-trimester procedural abortions.
Study Design: We performed an unblinded, randomized, noninferiority trial of people undergoing second-trimester procedural abortion at 18 + 0 to 23 + 6 weeks' gestation. We randomized participants to either overnight osmotic dilators (Dilapan-S) or transcervical balloon (Foley).
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