J Exp Med
Institut für Medizinische Mikrobiologie und Hygiene, Eberhard-Karls-Universität, Elfriede-Aulhorn-Strasse 6, 72076 Tübingen, Germany.
Published: November 2004
Bartonella henselae causes vasculoproliferative disorders in humans. We identified a nonfimbrial adhesin of B. henselae designated as Bartonella adhesin A (BadA). BadA is a 340-kD outer membrane protein encoded by the 9.3-kb badA gene. It has a modular structure and contains domains homologous to the Yersinia enterocolitica nonfimbrial adhesin (Yersinia adhesin A). Expression of BadA was restored in a BadA-deficient transposon mutant by complementation in trans. BadA mediates the binding of B. henselae to extracellular matrix proteins and to endothelial cells, possibly via beta1 integrins, but prevents phagocytosis. Expression of BadA is crucial for activation of hypoxia-inducible factor 1 in host cells by B. henselae and secretion of proangiogenic cytokines (e.g., vascular endothelial growth factor). BadA is immunodominant in B. henselae-infected patients and rodents, indicating that it is expressed during Bartonella infections. Our results suggest that BadA, the largest characterized bacterial protein thus far, is a major pathogenicity factor of B. henselae with a potential role in the induction of vasculoproliferative disorders.
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http://dx.doi.org/10.1084/jem.20040500 | DOI Listing |
Microbiol Spectr
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Laboratory of Bacterial Zoonoses, International Research Center for Infectious Diseases, Research Institute for Microbial Diseases, Osaka University, Suita, Osaka, Japan.
a Gram-negative facultative intracellular bacterium, is the etiological agent of cat-scratch disease and also causes bacillary angiomatosis in immunocompromised individuals. Although the ability to promote vascular endothelial cell proliferation differs among species, variations among strains within remain unclear. angiogenic factor A (BafA) and adhesin A (BadA) have been identified as autotransporters of that are involved in endothelial cell proliferation.
View Article and Find Full Text PDFPLoS Pathog
September 2024
Mitrani Department of Desert Ecology, Swiss Institute for Dryland Environmental and Energy Research, Ben-Gurion University of the Negev, Midreshet Ben-Gurion, Israel.
Front Microbiol
November 2023
Department of Parasitology, Faculty of Science, Charles University, Prague, Czechia.
Bartonelloses are neglected emerging infectious diseases caused by facultatively intracellular bacteria transmitted between vertebrate hosts by various arthropod vectors. The highest diversity of species has been identified in rodents. Within this study we focused on the edible dormouse (), a rodent with unique life-history traits that often enters households and whose possible role in the epidemiology of infections had been previously unknown.
View Article and Find Full Text PDFMicrobes Infect
November 2023
Institute of Medical Microbiology and Infection Control, Goethe University, Paul Ehrlich Straße 40, 60596, Frankfurt, Germany. Electronic address:
Human pathogenic bacteria circulating in the bloodstream need to find a way to interact with endothelial cells (ECs) lining the blood vessels to infect and colonise the host. The extracellular matrix (ECM) of ECs might represent an attractive initial target for bacterial interaction, as many bacterial adhesins have reported affinities to ECM proteins, in particular to fibronectin (Fn). Here, we analysed the general role of EC-expressed Fn for bacterial adhesion.
View Article and Find Full Text PDFInfect Immun
March 2023
Department of Microbiology, Fujita Health University School of Medicine, Toyoake, Aichi, Japan.
species are hemotropic, facultative intracellular bacteria, some of which cause zoonoses, that are widely disseminated among many mammals, including humans. During infection in humans, vascular endothelial cells play a crucial role as a replicative niche for , and some are capable of promoting vascular proliferation. Along with well-studied pathogenic factors such as a trimeric autotransporter adhesin BadA or VirB/D4 type IV secretion system, bacteria-secreted protein BafA is also involved in -induced vasoproliferation.
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