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FDG-PET CT for tumor imaging.
J Am Coll Radiol
April 2007
Department of Radiology, Massachusetts General Hospital, Boston, MA 02114, USA.
Using imaging biomarkers to accelerate drug development and clinical trials.
Drug Discov Today
February 2005
Department of Radiology, Massachusetts General Hospital, 55 Fruit Street, Boston, MA 02114, USA.
There is increasing evidence that human medical imaging can help answer key questions that arise during the drug development process. Imaging modalities such as magnetic resonance imaging, computed tomography and positron emission tomography can offer significant insights into the bioactivity, pharmacokinetics and dosing of drugs, in addition to supporting registration applications. In this review, examples from oncology, neurology, psychiatry, infectious diseases and inflammatory diseases are used to illustrate the role imaging can play.
View Article and Find Full Text PDFSynthesis of [11C]dapoxetine.HCl, a serotonin re-uptake inhibitor: biodistribution in rat and preliminary PET imaging in the monkey.
Nucl Med Biol
May 1994
Department of Radiology, Massachusetts General Hospital, Boston 02114, USA.
[11C]Dapoxetine.HCl, S-(+)-N,N-dimethyl-a-[2-(naphthalenyloxy)ethyl] benzenemethanamine hydrochloride, a potent serotonin re-uptake inhibitor was prepared from its mono-methyl precursor, S-(+)-N-methyl-a-[2-(naphthalenyloxy)ethyl]benzene methanamine hydrochloride. Biodistribution was determined in rats at 5, 30 and 60 min after injection and preliminary PET studies were performed in a Rhesus monkey.
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