Vitrectomy is the most common surgical technique performed in eyes with vitreoretinal disease. The development and widespread use of vitreous substitutes has revolutionized vitreoretinal surgery and improved anatomic and visual results. The three most common types of vitreous substitutes available in North America include silicone oil, intraocular gas, and perfluorocarbon liquid. Each of these agents has unique properties, allowing completely different roles of the agents in vitreoretinal surgery. The physical properties, clinical indications, and potential complications of these agents are described.
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| http://dx.doi.org/10.1016/j.ohc.2004.06.011 | DOI Listing |
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Article Synopsis
- - The study examines how a monoclonal antibody (bevacizumab) interacts with silicone oils and hydrogels, revealing that exposure to silicone oils significantly decreases the antibody's functionality and causes aggregation.
- - Results show that after 24 hours in silicone oil, bevacizumab retains only 30% of its activity, leading to concerns about its clinical use during procedures that involve silicone oil tamponade.
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