AI Article Synopsis
- Researchers tested nine Brazilian plant species for their ability to combat malaria by examining their extracts for antiplasmodial activity.
- The study focused on alkaloid and ethanol extracts against resistant and sensitive strains of Plasmodium falciparum, finding that alkaloid extracts were generally more effective.
- Notably, Guatteria australis showed the highest activity with an IC(50) of 0.3 microg/mL, with three species identified as promising for further research based on their low IC(50) values.
Article Abstract
In the search for new antimalarial agents, nine Brazilian plant species were selected, from the Annonaceae (6), Menispermaceae (2) and Siparunaceae (1) families naturally occurring at the cerrado and Atlantic rainforest regions, in order to investigate their in vitro antiplasmodial activity. The ethanol and the alkaloid extracts were tested against K1, chloroquine-resistant, and Palo Alto, chloroquine-sensitive, strains of Plasmodium falciparum. The majority of the alkaloid extracts were more active than the ethanol ones, with IC(50) ranging 0.3-8.2 microg/mL. The crude Guatteria australis alkaloids were the most active against K1 with an IC(50) = 0.3 microg/mL. The most promising total alkaloid fractions for further bioguided isolation are those with the IC(50) < or = 5 microg/mL: G. australis, Cissampelos ovalifolia and Duguetia lanceolata.
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| http://dx.doi.org/10.1016/j.actatropica.2004.08.009 | DOI Listing |
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