Objectives: The widespread use and broad acceptance of osseointegrated dental implants as a means of retaining and supporting mandibular overdentures provide potentially stable three-dimensional reference structures, which have been used to examine the morphological changes of the surface contours of the mandibular ridges distal to implants. Unlike traditional methods that tended to measure changes in ridge morphology and quantity radiographically, this prospective study investigated the changes in the sagittal surface contours of the posterior residual ridges over a 1-year period by an alternative, non-radiographic method using serial casts of residual ridges of a group of patients.
Material And Methods: The residual ridges of the serial casts produced were examined using a profiling apparatus and computer software programs that allowed the orientation, digitised recording and measurement of the sagittal surface contours of the posterior residual ridges of mandibular casts in terms of area (cm(2)).
Results: Statistical analysis revealed that the detected reductive changes in the surface contour of the posterior residual ridges following the wearing of an implant-retained mandibular overdenture over a 1-year period were highly significant (P<0.001).
Conclusion: It is concluded that the methodology presented in this study can be used reliably as an alternative to radiographical examination for detecting changes that occur in the distal residual alveolar ridges of the implant containing edentulous mandible when implant-retained overdentures are used. Thus, the method presented may be used to contribute to a reduced exposure to ionising radiation for patients wearing implant-retained overdentures.
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http://dx.doi.org/10.1111/j.1600-0501.2004.01057.x | DOI Listing |
Clin Pharmacol Drug Dev
January 2025
Department of Pharmacometrics Modeling, A2-Ai LLC, Ann Arbor, MI, USA.
Certepetide (aka LSTA1 and CEND-1) is a novel cyclic tumor-targeting internalizing arginyl glycylaspartic acid peptide being developed to treat solid tumors. Certepetide is designed to overcome existing challenges in treating solid tumors by delivering co-administered anticancer drugs into the tumor while selectively depleting immunosuppressive T cells, enhancing cytotoxic T cells in the tumor microenvironment, and inhibiting the metastatic cascade. A population pharmacokinetic (PK) analysis was conducted to characterize the concentration-time profile of patients with metastatic exocrine pancreatic cancer receiving certepetide in combination with nab-paclitaxel and gemcitabine, and to investigate the effects of clinically relevant covariates on PK parameters.
View Article and Find Full Text PDFAnn Anat
January 2025
Department of Dental Clinical Specialties, Faculty of Dentistry, Complutense University of Madrid, Spain; Surgical and Implant Therapies in the Oral Cavity Research Group; University Complutense, Madrid, Spain.
Background: The aim of this study was to analyze the histomorphometric findings of autogenous tooth grafting (ATG) for alveolar ridge preservation (ARP), using graft material from extracted teeth. Variations by sex, age and location of extracted teeth, as well as any associated complications, were also assessed.
Materials And Methods: This prospective, single-cohort study was conducted using ATG placed in extraction sockets.
J Pediatr Orthop
February 2025
Orthopaedic Surgery and Sports Medicine, Akron Children's Hospital, Columbus, OH.
BMC Oral Health
January 2025
Department of Oral Implantology, School and Hospital of Stomatology, Guangdong Engineering Research Center of Oral Restoration and Reconstruction & Guangzhou Key Laboratory of Basic and Applied Research of Oral Regenerative Medicine, Guangzhou Medical University, Guangzhou, 510182, China.
Background: Fibrous dysplasia (FD) is a self-limiting benign disease with slow progression in which the normal bone is replaced by dysplastic fibrous tissue. The craniofacial skeleton is one of the most commonly affected areas, and it can create unique challenges in dental implant therapy. This case aims to report an unusual presentation of FD localized in the alveolar crest bone of the edentulous site, causing special obstacles to implant placement, and provide a diagnostic and treatment process that may be referenced.
View Article and Find Full Text PDFOral Maxillofac Surg
December 2024
Department of Oral Implantology, Osaka Dental University, 8-1 Kuzuhahanazonocho, Hirakata, 573-1121, Osaka, Japan.
Background: The pre-extraction overbuilding procedure was designed aiming to mitigate buccal bone resorption following tooth extraction. The objective of this study was to compare the efficacy of pre-extraction and juxta-extraction buccal overbuilding treatments in preserving buccal bone volume following tooth extraction.
Material And Methods: At the test sites (pre-extraction sites), an alveolar crest overbuilding was performed on the buccal aspect of the distal root of the fourth premolar using a xenograft covered with a collagen membrane.
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