Distortion product otoacoustic emissions (DPOAEs) at 2f1-f2 (f2/f1 = 1.2) have two components from different cochlear sources, i.e., a distortion component generated near f2 and a reflection component from the characteristic site of fDP. The interaction of the two sources may negatively affect the DPOAE input/output (I/O) functions that are used to predict either auditory thresholds or the compression characteristics of the basilar membrane. This study investigates the influence of the reflection component on DPOAE I/O functions in a frequency range for f2 from 1500 to 4500 Hz in steps of 18 Hz. A time windowing procedure is used to separate the components from the two DPOAE sources. With decreasing stimulus level, the relative contribution of the reflection component increases. I/O functions from the separated distortion component (DCOAE I/O functions) only show smooth changes in shape and slope with frequency, while "standard" DPOAE I/O functions show rapid changes between adjacent frequencies, indicating a strong influence from the interference with the second DPOAE source. A reduced variability for adjacent frequencies can be seen as well for prediction of hearing thresholds, when using DCOAE instead of DPOAE I/O functions.
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Sci Rep
January 2025
Department of Pathology, Dokkyo Medical University School of Medicine and Graduate School of Medicine, 880 Kitakobayashi, Mibu, Shimotsugagun, Tochigi, 321-0293, Japan.
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January 2025
Department of Physiology, College of Medicine Gyeongsang National University Jinju Republic of Korea.
Our previous study highlighted the anticancer potential of sea hare hydrolysate (SHH), particularly its role in regulating macrophage polarization and inducing pyroptotic death in lung cancer cells through the inhibition of signal transducer and activator of transcription 3 (STAT3). These findings prompted us to investigate additional features of immune-oncology (I-O) agents or adjuvants, such as programmed cell death protein 1 (PD-1)/programmed death ligand 1 (PD-L1) inhibition and their association with rheumatoid arthritis (RA) risk, to explore the potential of SHH as an I-O agent or adjuvant. In this study, we investigated the effects of SHH on PD-L1 levels in various cancer cell types and assessed its effectiveness in treating RA, a common side effect of I-O agents.
View Article and Find Full Text PDFNpj Flex Electron
October 2024
Thayer School of Engineering, Dartmouth College, Hanover, NH, 03755, USA.
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View Article and Find Full Text PDFPhysiol Rep
January 2025
Department of Kinesiology, James Madison University, Harrisonburg, Virginia, USA.
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View Article and Find Full Text PDFViruses
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World Health Organization, 1202 Geneva, Switzerland.
Setting up a global SARS-CoV-2 surveillance system requires an understanding of how virus isolation and propagation practices, use of animal or human sera, and different neutralisation assay platforms influence assessment of SARS-CoV-2 antigenicity. In this study, with the contribution of 15 independent laboratories across all WHO regions, we carried out a controlled analysis of neutralisation assay platforms using the first WHO International Standard for antibodies to SARS-CoV-2 variants of concern (source: NIBSC). Live virus isolates (source: WHO BioHub or individual labs) or spike plasmids (individual labs) for pseudovirus production were used to perform neutralisation assays using the same serum panels.
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