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Highly multiplexed imaging reveals prognostic immune and stromal spatial biomarkers in breast cancer.
JCI Insight
January 2025
Department of Biomedical Engineering, Oregon Health and Science University, Portland, United States of America.
Spatial profiling of tissues promises to elucidate tumor-microenvironment interactions and generate prognostic and predictive biomarkers. We analyzed single-cell, spatial data from three multiplex imaging technologies: cyclic immunofluorescence (CycIF) data we generated from 102 breast cancer patients with clinical follow-up, and publicly available imaging mass cytometry and multiplex ion-beam imaging datasets. Similar single-cell phenotyping results across imaging platforms enabled combined analysis of epithelial phenotypes to delineate prognostic subtypes among estrogen-receptor positive (ER+) patients.
View Article and Find Full Text PDFImpaired hydrogen sulfide biosynthesis underlies eccentric contraction-induced force loss in dystrophin-deficient skeletal muscle.
J Clin Invest
January 2025
Department of Biochemistry, Molecular Biology & Biophysics, University of Minnesota, Minneapolis, United States of America.
Eccentric contraction- (ECC) induced force loss is a hallmark of murine dystrophin-deficient (mdx) skeletal muscle that is used to assess efficacy of potential therapies for Duchenne muscular dystrophy. While virtually all key proteins involved in muscle contraction have been implicated in ECC force loss, a unifying mechanism that orchestrates force loss across such diverse molecular targets has not been identified. We showed that correcting defective hydrogen sulfide (H2S) signaling in mdx muscle prevented ECC force loss.
View Article and Find Full Text PDFThe Association Between COVID-19 Vaccination Uptake and Information-Seeking Behaviors Using the Internet: Nationwide Cross-Sectional Study.
J Med Internet Res
January 2025
Department of Healthcare Economics and Quality Management, School of Public Health, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
Background: The COVID-19 pandemic, declared in March 2020, profoundly affected global health, societal, and economic frameworks. Vaccination became a crucial tactic in combating the virus. Simultaneously, the pandemic likely underscored the internet's role as a vital resource for seeking health information.
View Article and Find Full Text PDFPrevalence of Mental Illness Among Middle Adolescents in Jeddah, Saudi Arabia.
J Psychosoc Nurs Ment Health Serv
January 2025
Purpose: To assess the prevalence of mental illness among middle adolescents (aged 14 to 17 years) in Jeddah, Saudi Arabia.
Method: A quantitative, cross-sectional study was conducted among 483 students aged 14 to 17 years attending intermediate and secondary schools in Jeddah, Saudi Arabia. Participants were asked to complete the Arabic version of the self-reported Strengths and Difficulties Questionnaire (SDQ).
Effects of Art Therapy on Quality of Life and Social Functioning in Individuals With Schizophrenia.
J Psychosoc Nurs Ment Health Serv
January 2025
Purpose: To investigate the effect of art therapy on quality of life and social functioning of individuals with schizophrenia receiving community mental health services.
Method: A quasi-experimental study design was used to assess the effects of art therapy on quality of life and social functioning. The study included 14 participants with schizophrenia, seven assigned to the intervention group and seven to the control group.
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