Aim Of The Study: To assess the diagnostic value of RT-PCR on amniotic fluid (AF) for prenatal diagnosis of congenital rubella infection.
Material And Methods: RT-PCR on AF was compared to specific IgM antibody detection in foetuses and/or newborns in 45 pregnant women with confirmed primary infection.
Results: specificity of RT-PCR was 100% and sensitivity ranged between 83 and 95%.
Conclusion: RT PCR may be considered as a valuable tool for prenatal diagnosis of foetal rubella infection.
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| http://dx.doi.org/10.1016/j.patbio.2004.06.004 | DOI Listing |
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