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Mechanism and Kinetics of HIV-1 Protease Activation.
Viruses
November 2024
Center for Proteomics and Bioinformatics, Department of Nutrition, School of Medicine, Case Western Reserve University, Cleveland, OH 44106, USA.
The HIV-1 protease is a critical enzyme for viral replication. Because protease activity is necessary to generate mature infectious virions, it is a primary target of antiretroviral treatment. Here, we provide an overview of the mechanisms regulating protease activation and the methods available to assess protease activity.
View Article and Find Full Text PDFDevelopment of Inductive Current Transformer 400/5/1 of Class 0.2S for Frequency Range 50 Hz-5 kHz.
Sensors (Basel)
December 2024
Institute of Mechatronics and Information Systems, Lodz University of Technology, 90-537 Lodz, Poland.
This paper is devoted to the development of a window-type inductive current transformer (iCT) with a rated primary current equal to 400 A and two secondary windings with rated currents of 5 A and 1 A. Its novelty concerns the presentation of this process in the case of an iCT with a 0.2S accuracy class ensured not only for a sinusoidal current of a frequency of 50 Hz but also for the transformation of distorted current in the harmonic frequency range from 50 Hz to 5 kHz.
View Article and Find Full Text PDFResearch on the Stress Characteristics of Reuse of Semi-Rigid Base.
Sensors (Basel)
December 2024
School of Highway, Chang'an University, Middle Section of South Erhuan Road, Xi'an 710064, China.
Semi-rigid bases are widely used in road construction due to their excellent properties, high rigidity, and frost resistance, and they have been in service for many years. However, as the service life increases, the maintenance demands also grow, with traditional maintenance methods still being the primary approach. Based on a typical case using ground-penetrating radar (GPR) technology, this study explores the issue of cracks in semi-rigid bases and their impact on overlay layers.
View Article and Find Full Text PDFAntigenic Imprinting Dominates Humoral Responses to New Variants of SARS-CoV-2 in a Hamster Model of COVID-19.
Microorganisms
December 2024
KU Leuven, Department of Microbiology, Immunology & Transplantation, Rega Institute, Virology, Antiviral Drug and Vaccine Research Group, Laboratory of Molecular Vaccinology & Vaccine Discovery (MVVD), 3000 Leuven, Belgium.
The emergence of SARS-CoV-2 variants escaping immunity challenges the efficacy of current vaccines. Here, we investigated humoral recall responses and vaccine-mediated protection in Syrian hamsters immunized with the third-generation Comirnaty Omicron XBB.1.
View Article and Find Full Text PDFPort-a-Cath Infection of : First Italian Case Report.
Microorganisms
November 2024
Department of Microbiology & Virology, Fondazione IRCCS Policlinico San Matteo, 27100 Pavia, Italy.
is a Non-Tuberculous Mycobacterium (NTM) belonging to the group, often associated with veterinary diseases, such as bovine farcy. However, it can also cause human infections and appears to be involved in Catheter-Associated Infections in immunocompromised patients. Here, we report the first Italian isolation of a strain of from a 16-year-old oncological female patient being treated at Fondazione IRCCS Policlinico San Matteo Pavia (Italy).
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